Cargando…

Bacterial Heat-Stable Enterotoxins: Translation of Pathogenic Peptides into Novel Targeted Diagnostics and Therapeutics

Heat-stable toxins (STs) produced by enterotoxigenic bacteria cause endemic and traveler’s diarrhea by binding to and activating the intestinal receptor guanylyl cyclase C (GC-C). Advances in understanding the biology of GC-C have extended ST from a diarrheagenic peptide to a novel therapeutic agent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Jieru E., Valentino, Michael, Marszalowicz, Glen, Magee, Michael S., Li, Peng, Snook, Adam E., Stoecker, Brian A., Chang, Chang, Waldman, Scott A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153287/ https://www.ncbi.nlm.nih.gov/pubmed/22069671 http://dx.doi.org/10.3390/toxins2082028

Ejemplares similares

GUCY2C-targeted chimeric antigen receptor expressing T cells extend survival in a therapeutic mouse model of metastatic colorectal cancer
por: Magee, Michael S, et al.
Publicado: (2013)

GUCY2C lysosomotropic endocytosis delivers immunotoxin therapy to metastatic colorectal cancer
por: Marszalowicz, Glen P., et al.
Publicado: (2014)

GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity
por: Magee, Michael S., et al.
Publicado: (2016)

Topological Regulation of the Bioactive Conformation of a Disulfide-Rich Peptide, Heat-Stable Enterotoxin
por: Shimamoto, Shigeru, et al.
Publicado: (2020)

The Heat-Stable Enterotoxin Receptor, Guanylyl Cyclase C, as a Pharmacological Target in Colorectal Cancer Immunotherapy: A Bench-to-Bedside Current Report
por: Baybutt, Trevor R., et al.
Publicado: (2017)

Heat-Stable Enterotoxins of Enterotoxigenic Escherichia coli and Their Impact on Host Immunity
por: Wang, Haixiu, et al.
Publicado: (2019)

GUCY2C Opposes Systemic Genotoxic Tumorigenesis by Regulating AKT-Dependent Intestinal Barrier Integrity
por: Lin, Jieru Egeria, et al.
Publicado: (2012)

From Escherichia coli heat-stable enterotoxin to mammalian endogenous guanylin hormones
por: Lima, A.A.M., et al.
Publicado: (2014)

The Molecular Basis of Heat-Stable Enterotoxin for Vaccine Development and Cancer Cell Detection
por: Goto, Masaya, et al.
Publicado: (2023)

A Novel CDX2 Isoform Regulates Alternative Splicing
por: Witek, Matthew E., et al.
Publicado: (2014)

Heat-stable enterotoxin-producing Escherichia coli O169:H41 in Japan.
por: Nishikawa, Y, et al.
Publicado: (1995)

Impact of the Escherichia coli Heat-Stable Enterotoxin b (STb) on Gut Health and Function
por: Butt, Shahnawaz, et al.
Publicado: (2020)

Cure and Curse: E. coli Heat-Stable Enterotoxin and Its Receptor Guanylyl Cyclase C
por: Weiglmeier, Philipp R., et al.
Publicado: (2010)

Campomanesia adamantium Peel Extract in Antidiarrheal Activity: The Ability of Inhibition of Heat-Stable Enterotoxin by Polyphenols
por: Lescano, Caroline Honaiser, et al.
Publicado: (2016)

Staphylococcal Enterotoxins Promote Virulence in Bacterial Keratitis
por: Johnson, William L., et al.
Publicado: (2023)

DIARRHEA OUTBREAK IN PERNAMBUCO, BRAZIL, ASSOCIATED WITH A HEAT-STABLE CYTOTOXIC ENTEROTOXIN PRODUCED BY Aeromonas caviae
por: LOPES, Ana Carolina Amaral, et al.
Publicado: (2015)

Bactericidal Effect of Selected Antidiarrhoeal Medicinal Plants on Intracellular Heat-Stable Enterotoxin-Producing Escherichia coli
por: Birdi, Tannaz J., et al.
Publicado: (2014)

Establishment and application of isothermal amplification techniques for the detection of heat-stable I enterotoxin of enterotoxigenic Escherichia coli
por: Zhai, Junjun, et al.
Publicado: (2020)

Purification of heat-labile enterotoxin from an enterotoxin from an enterotoxigenic Escherichia coli of human origin by monoclonal immunoaffinity chromatography.
por: Cho, M. J., et al.
Publicado: (1987)

GUCY2C at the intersection of obesity and colorectal cancer
por: Waldman, Scott A, et al.
Publicado: (2013)

Role of Heat-Stable Enterotoxins in the Induction of Early Immune Responses in Piglets after Infection with Enterotoxigenic Escherichia coli
por: Loos, Michaela, et al.
Publicado: (2012)

Experimental Infection of Human Volunteers with the Heat-Stable Enterotoxin-Producing Enterotoxigenic Escherichia coli Strain TW11681
por: Todnem Sakkestad, Sunniva, et al.
Publicado: (2019)

Preparation of biocompatible heat-labile enterotoxin subunit B-bovine serum albumin nanoparticles for improving tumor-targeted drug delivery via heat-labile enterotoxin subunit B mediation
por: Zhao, Liang, et al.
Publicado: (2014)

Heat-labile enterotoxin enhances F4-producing enterotoxigenic E. coli adhesion to porcine intestinal epithelial cells by upregulating bacterial adhesins and STb enterotoxin
por: Duan, Qiangde, et al.
Publicado: (2022)

ST-Producing E. coli Oppose Carcinogen-Induced Colorectal Tumorigenesis in Mice
por: Li, Peng, et al.
Publicado: (2017)

Clostridium perfringens Enterotoxin: Action, Genetics, and Translational Applications
por: Freedman, John C., et al.
Publicado: (2016)

Both LTA and LTB Subunits Are Equally Important to Heat-Labile Enterotoxin (LT)-Enhanced Bacterial Adherence
por: Duan, Qiangde, et al.
Publicado: (2023)

Heat-Labile Enterotoxin Decreases Macrophage Phagocytosis of Enterotoxigenic Escherichia coli
por: Hollifield, Ian E., et al.
Publicado: (2023)

Development of Thermally Stable Nanobodies for Detection and Neutralization of Staphylococcal Enterotoxin B
por: Hughes, Anna C., et al.
Publicado: (2023)

Staphylococcal Enterotoxins
por: Pinchuk, Irina V., et al.
Publicado: (2010)

Heat-Labile Enterotoxin: Beyond G(M1) Binding
por: Mudrak, Benjamin, et al.
Publicado: (2010)

Lack of Restoration in Vivo by K(+)-Channel Modulators of Jejunal Fluid Absorption after Heat Stable Escherichia coli Enterotoxin (STa) Challenge
por: Lucas, M. L., et al.
Publicado: (2011)

AU richness within the 5′ coding region of the Escherichia coli heat-stable enterotoxin b mRNA affects toxin secretion
por: Kinkar, Eyad, et al.
Publicado: (2020)

Characterization of the ganglioside recognition profile of Escherichia coli heat-labile enterotoxin LT-IIc
por: Zalem, Dani, et al.
Publicado: (2021)

Heat-Stable Enterotoxin Secretions Assessed via ICP-MS Reveal Iron-Mediated Regulation of Virulence in CFA/I- and CS6-Expressing ETEC Isolates
por: Hollifield, Ian E., et al.
Publicado: (2023)

The Suppressive Activities of Six Sources of Medicinal Ferns Known as Gusuibu on Heat-Labile Enterotoxin-Induced Diarrhea
por: Chang, Hung-Chi, et al.
Publicado: (2014)

Escherichia coli Heat-Stable Enterotoxin Mediates Na(+)/H(+) Exchanger 4 Inhibition Involving cAMP in T(84) Human Intestinal Epithelial Cells
por: Beltrán, Ana R., et al.
Publicado: (2015)

Detection and genetic analysis of the enteroaggregative Escherichia coli heat-stable enterotoxin (EAST1) gene in clinical isolates of enteropathogenic Escherichia coli (EPEC) strains
por: Silva, Lucas EP, et al.
Publicado: (2014)

Heat-Labile Enterotoxin IIa, a Platform To Deliver Heterologous Proteins into Neurons
por: Chen, Chen, et al.
Publicado: (2015)

Concerted Action of Sphingomyelinase and Non-Hemolytic Enterotoxin in Pathogenic Bacillus cereus
por: Doll, Viktoria M., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_kaomd2mde34nikajsmrg89mvhv