Restoration of Regenerative Osteoblastogenesis in Aged Mice: Modulation of TNF

Skeletal changes accompanying aging are associated with both increased risk of fractures and impaired fracture healing, which, in turn, is due to compromised bone regeneration potential. These changes are associated with increased serum levels of selected proinflammatory cytokines, e.g., tumor necro...

Descripción completa

Detalles Bibliográficos
Autores principales: Wahl, Elizabeth C, Aronson, James, Liu, Lichu, Fowlkes, John L, Thrailkill, Kathryn M, Bunn, Robert C, Skinner, Robert A, Miller, Mike J, Cockrell, Gael E, Clark, Lindsey M, Ou, Yang, Isales, Carlos M, Badger, Thomas M, Ronis, Martin J, Sims, John, Lumpkin, Charles K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153322/
https://www.ncbi.nlm.nih.gov/pubmed/19580462
http://dx.doi.org/10.1359/jbmr.090708
Descripción
Sumario:Skeletal changes accompanying aging are associated with both increased risk of fractures and impaired fracture healing, which, in turn, is due to compromised bone regeneration potential. These changes are associated with increased serum levels of selected proinflammatory cytokines, e.g., tumor necrosis factor α (TNF-α). We have used a unique model of bone regeneration to demonstrate (1) that aged-related deficits in direct bone formation can be restored to young mice by treatment with TNF blockers and (2) that the cyclin-dependent kinase inhibitor p21 is a candidate for mediation of the osteoinhibitory effects of TNF. It has been hypothesized recently that TNF antagonists may represent novel anabolic agents, and we believe that the data presented here represent a successful test of this hypothesis. © 2010 American Society for Bone and Mineral Research

Ejemplares similares