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Kinetic Analysis of Substrate Utilization by Native and TNAP-, NPP1-, or PHOSPHO1-Deficient Matrix Vesicles

During the process of endochondral bone formation, chondrocytes and osteoblasts mineralize their extracellular matrix by promoting the formation of hydroxyapatite seed crystals in the sheltered interior of membrane-limited matrix vesicles (MVs). Here, we have studied phosphosubstrate catalysis by os...

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Detalles Bibliográficos
Autores principales:	Ciancaglini, Pietro, Yadav, Manisha C, Simão, Ana Maria Sper, Narisawa, Sonoko, Pizauro, João Martins, Farquharson, Colin, Hoylaerts, Marc F, Millán, José Luis
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153326/ https://www.ncbi.nlm.nih.gov/pubmed/19874193 http://dx.doi.org/10.1359/jbmr.091023

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