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Kinetic Analysis of Substrate Utilization by Native and TNAP-, NPP1-, or PHOSPHO1-Deficient Matrix Vesicles
During the process of endochondral bone formation, chondrocytes and osteoblasts mineralize their extracellular matrix by promoting the formation of hydroxyapatite seed crystals in the sheltered interior of membrane-limited matrix vesicles (MVs). Here, we have studied phosphosubstrate catalysis by os...
Autores principales: | Ciancaglini, Pietro, Yadav, Manisha C, Simão, Ana Maria Sper, Narisawa, Sonoko, Pizauro, João Martins, Farquharson, Colin, Hoylaerts, Marc F, Millán, José Luis |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wiley Subscription Services, Inc., A Wiley Company
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153326/ https://www.ncbi.nlm.nih.gov/pubmed/19874193 http://dx.doi.org/10.1359/jbmr.091023 |
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