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Overexpression of Secreted Frizzled-Related Protein 1 Inhibits Bone Formation and Attenuates Parathyroid Hormone Bone Anabolic Effects

Secreted frizzled-related protein 1 (sFRP1) is an antagonist of Wnt signaling, an important pathway in maintaining bone homeostasis. In this study we evaluated the skeletal phenotype of mice overexpressing sFRP1 (sFRP1 Tg) and the interaction of parathyroid hormone (PTH) treatment and sFRP1 (over)ex...

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Detalles Bibliográficos
Autores principales:	Yao, Wei, Cheng, Zhiqiang, Shahnazari, Mohammad, Dai, Wewei, Johnson, Mark L, Lane, Nancy E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153380/ https://www.ncbi.nlm.nih.gov/pubmed/19594295 http://dx.doi.org/10.1359/jbmr.090719

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