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Bone Marrow Changes in Adolescent Girls With Anorexia Nervosa

Early osteoporosis is common among adolescent girls with anorexia nervosa (AN) and may result from premature conversion of red (RM) to yellow bone marrow. We performed right knee magnetic resonance imaging (MRI) on a 1.0 T extremity scanner in 20 patients and 20 healthy controls, aged 16.2 ± 1.6 yea...

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Autores principales: Ecklund, Kirsten, Vajapeyam, Sridhar, Feldman, Henry A, Buzney, Catherine D, Mulkern, Robert V, Kleinman, Paul K, Rosen, Clifford J, Gordon, Catherine M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153386/
https://www.ncbi.nlm.nih.gov/pubmed/19653811
http://dx.doi.org/10.1359/jbmr.090805
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author Ecklund, Kirsten
Vajapeyam, Sridhar
Feldman, Henry A
Buzney, Catherine D
Mulkern, Robert V
Kleinman, Paul K
Rosen, Clifford J
Gordon, Catherine M
author_facet Ecklund, Kirsten
Vajapeyam, Sridhar
Feldman, Henry A
Buzney, Catherine D
Mulkern, Robert V
Kleinman, Paul K
Rosen, Clifford J
Gordon, Catherine M
author_sort Ecklund, Kirsten
collection PubMed
description Early osteoporosis is common among adolescent girls with anorexia nervosa (AN) and may result from premature conversion of red (RM) to yellow bone marrow. We performed right knee magnetic resonance imaging (MRI) on a 1.0 T extremity scanner in 20 patients and 20 healthy controls, aged 16.2 ± 1.6 years (mean ± SD). Coronal T(1)-weighted (T(1)W) images and T(1) maps were generated from T(1) relaxometry images. Blinded radiologists visually assessed RM in the distal femoral and proximal tibial metaphyses in T(1)W images using a scale of signal intensity from 0 (homogeneous hyperintensity, no RM) to 4 (all dark, complete RM). Subjects with AN exhibited nearly twofold lower metaphyseal RM scores in both the femur (0.64 versus 1.22, p = .03) and tibia (0.54 versus 0.96, p = .08). In relaxometric measurements of four selected regions (femur and tibia amd epiphysis and metaphysis), subjects with AN showed higher mean epiphyseal but lower metaphyseal T(1). The net AN-control difference between epiphysis and metaphysis was 70 ms in the femur (+31 versus −35 ms, p = .02) and of smaller magnitude in the tibia. In relaxometry data from the full width of the femur adjacent to the growth plate, AN subjects showed mean T(1) consistently lower than in controls by 30 to 50 ms in virtually every part of the sampling region. These findings suggest that adolescents with AN exhibit premature conversion of hematopoietic to fat cells in the marrow of the peripheral skeleton potentially owing to adipocyte over osteoblast differentiation in the mesenchymal stem cell pool. © 2010 American Society for Bone and Mineral Research
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spelling pubmed-31533862011-08-19 Bone Marrow Changes in Adolescent Girls With Anorexia Nervosa Ecklund, Kirsten Vajapeyam, Sridhar Feldman, Henry A Buzney, Catherine D Mulkern, Robert V Kleinman, Paul K Rosen, Clifford J Gordon, Catherine M J Bone Miner Res Original Article Early osteoporosis is common among adolescent girls with anorexia nervosa (AN) and may result from premature conversion of red (RM) to yellow bone marrow. We performed right knee magnetic resonance imaging (MRI) on a 1.0 T extremity scanner in 20 patients and 20 healthy controls, aged 16.2 ± 1.6 years (mean ± SD). Coronal T(1)-weighted (T(1)W) images and T(1) maps were generated from T(1) relaxometry images. Blinded radiologists visually assessed RM in the distal femoral and proximal tibial metaphyses in T(1)W images using a scale of signal intensity from 0 (homogeneous hyperintensity, no RM) to 4 (all dark, complete RM). Subjects with AN exhibited nearly twofold lower metaphyseal RM scores in both the femur (0.64 versus 1.22, p = .03) and tibia (0.54 versus 0.96, p = .08). In relaxometric measurements of four selected regions (femur and tibia amd epiphysis and metaphysis), subjects with AN showed higher mean epiphyseal but lower metaphyseal T(1). The net AN-control difference between epiphysis and metaphysis was 70 ms in the femur (+31 versus −35 ms, p = .02) and of smaller magnitude in the tibia. In relaxometry data from the full width of the femur adjacent to the growth plate, AN subjects showed mean T(1) consistently lower than in controls by 30 to 50 ms in virtually every part of the sampling region. These findings suggest that adolescents with AN exhibit premature conversion of hematopoietic to fat cells in the marrow of the peripheral skeleton potentially owing to adipocyte over osteoblast differentiation in the mesenchymal stem cell pool. © 2010 American Society for Bone and Mineral Research Wiley Subscription Services, Inc., A Wiley Company 2010-02 2009-08-03 /pmc/articles/PMC3153386/ /pubmed/19653811 http://dx.doi.org/10.1359/jbmr.090805 Text en Copyright © 2010 American Society for Bone and Mineral Research http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Original Article
Ecklund, Kirsten
Vajapeyam, Sridhar
Feldman, Henry A
Buzney, Catherine D
Mulkern, Robert V
Kleinman, Paul K
Rosen, Clifford J
Gordon, Catherine M
Bone Marrow Changes in Adolescent Girls With Anorexia Nervosa
title Bone Marrow Changes in Adolescent Girls With Anorexia Nervosa
title_full Bone Marrow Changes in Adolescent Girls With Anorexia Nervosa
title_fullStr Bone Marrow Changes in Adolescent Girls With Anorexia Nervosa
title_full_unstemmed Bone Marrow Changes in Adolescent Girls With Anorexia Nervosa
title_short Bone Marrow Changes in Adolescent Girls With Anorexia Nervosa
title_sort bone marrow changes in adolescent girls with anorexia nervosa
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153386/
https://www.ncbi.nlm.nih.gov/pubmed/19653811
http://dx.doi.org/10.1359/jbmr.090805
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