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Comparison of Metabolism of Vitamins D(2) and D(3) in Children With Nutritional Rickets

Children with calcium-deficiency rickets may have increased vitamin D requirements and respond differently to vitamin D(2) and vitamin D(3). Our objective was to compare the metabolism of vitamins D(2) and D(3) in rachitic and control children. We administered an oral single dose of vitamin D(2) or...

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Autores principales: Thacher, Tom D, Fischer, Philip R, Obadofin, Michael O, Levine, Michael A, Singh, Ravinder J, Pettifor, John M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153403/
https://www.ncbi.nlm.nih.gov/pubmed/20499377
http://dx.doi.org/10.1002/jbmr.99
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author Thacher, Tom D
Fischer, Philip R
Obadofin, Michael O
Levine, Michael A
Singh, Ravinder J
Pettifor, John M
author_facet Thacher, Tom D
Fischer, Philip R
Obadofin, Michael O
Levine, Michael A
Singh, Ravinder J
Pettifor, John M
author_sort Thacher, Tom D
collection PubMed
description Children with calcium-deficiency rickets may have increased vitamin D requirements and respond differently to vitamin D(2) and vitamin D(3). Our objective was to compare the metabolism of vitamins D(2) and D(3) in rachitic and control children. We administered an oral single dose of vitamin D(2) or D(3) of 1.25 mg to 49 Nigerian children—28 with active rickets and 21 healthy controls. The primary outcome measure was the incremental change in vitamin D metabolites. Baseline serum 25-hydroxyvitamin D [25(OH)D] concentrations ranged from 7 to 24 and 15 to 34 ng/mL in rachitic and control children, respectively (p < .001), whereas baseline 1,25-dihydroxyvitamin D [1,25(OH)(2)D] values (mean ± SD) were 224 ± 72 and 121 ± 34 pg/mL, respectively (p < .001), and baseline 24,25-dihydroxyvitamin D [24,25(OH)(2)D] values were 1.13 ± 0.59 and 4.03 ± 1.33 ng/mL, respectively (p < .001). The peak increment in 25(OH)D was on day 3 and was similar with vitamins D(2) and D(3) in children with rickets (29 ± 17 and 25 ± 11 ng/mL, respectively) and in control children (33 ± 13 and 31 ± 16 ng/mL, respectively). 1,25(OH)(2)D rose significantly (p < .001) and similarly (p = .18) on day 3 by 166 ± 80 and 209 ± 83 pg/mL after vitamin D(2) and D(3) administration, respectively, in children with rickets. By contrast, control children had no significant increase in 1,25(OH)(2)D (19 ± 28 and 16 ± 38 pg/mL after vitamin D(2) and D(3) administration, respectively). We conclude that in the short term, vitamins D(2) and D(3) similarly increase serum 25(OH)D concentrations in rachitic and healthy children. A marked increase in 1,25(OH)(2)D in response to vitamin D distinguishes children with putative dietary calcium-deficiency rickets from healthy children, consistent with increased vitamin D requirements in children with calcium-deficiency rickets. © 2010 American Society for Bone and Mineral Research.
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spelling pubmed-31534032011-09-01 Comparison of Metabolism of Vitamins D(2) and D(3) in Children With Nutritional Rickets Thacher, Tom D Fischer, Philip R Obadofin, Michael O Levine, Michael A Singh, Ravinder J Pettifor, John M J Bone Miner Res Original Article Children with calcium-deficiency rickets may have increased vitamin D requirements and respond differently to vitamin D(2) and vitamin D(3). Our objective was to compare the metabolism of vitamins D(2) and D(3) in rachitic and control children. We administered an oral single dose of vitamin D(2) or D(3) of 1.25 mg to 49 Nigerian children—28 with active rickets and 21 healthy controls. The primary outcome measure was the incremental change in vitamin D metabolites. Baseline serum 25-hydroxyvitamin D [25(OH)D] concentrations ranged from 7 to 24 and 15 to 34 ng/mL in rachitic and control children, respectively (p < .001), whereas baseline 1,25-dihydroxyvitamin D [1,25(OH)(2)D] values (mean ± SD) were 224 ± 72 and 121 ± 34 pg/mL, respectively (p < .001), and baseline 24,25-dihydroxyvitamin D [24,25(OH)(2)D] values were 1.13 ± 0.59 and 4.03 ± 1.33 ng/mL, respectively (p < .001). The peak increment in 25(OH)D was on day 3 and was similar with vitamins D(2) and D(3) in children with rickets (29 ± 17 and 25 ± 11 ng/mL, respectively) and in control children (33 ± 13 and 31 ± 16 ng/mL, respectively). 1,25(OH)(2)D rose significantly (p < .001) and similarly (p = .18) on day 3 by 166 ± 80 and 209 ± 83 pg/mL after vitamin D(2) and D(3) administration, respectively, in children with rickets. By contrast, control children had no significant increase in 1,25(OH)(2)D (19 ± 28 and 16 ± 38 pg/mL after vitamin D(2) and D(3) administration, respectively). We conclude that in the short term, vitamins D(2) and D(3) similarly increase serum 25(OH)D concentrations in rachitic and healthy children. A marked increase in 1,25(OH)(2)D in response to vitamin D distinguishes children with putative dietary calcium-deficiency rickets from healthy children, consistent with increased vitamin D requirements in children with calcium-deficiency rickets. © 2010 American Society for Bone and Mineral Research. Wiley Subscription Services, Inc., A Wiley Company 2010-09 2010-04-01 /pmc/articles/PMC3153403/ /pubmed/20499377 http://dx.doi.org/10.1002/jbmr.99 Text en Copyright © 2010 American Society for Bone and Mineral Research http://creativecommons.org/licenses/by/2.5/ Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
spellingShingle Original Article
Thacher, Tom D
Fischer, Philip R
Obadofin, Michael O
Levine, Michael A
Singh, Ravinder J
Pettifor, John M
Comparison of Metabolism of Vitamins D(2) and D(3) in Children With Nutritional Rickets
title Comparison of Metabolism of Vitamins D(2) and D(3) in Children With Nutritional Rickets
title_full Comparison of Metabolism of Vitamins D(2) and D(3) in Children With Nutritional Rickets
title_fullStr Comparison of Metabolism of Vitamins D(2) and D(3) in Children With Nutritional Rickets
title_full_unstemmed Comparison of Metabolism of Vitamins D(2) and D(3) in Children With Nutritional Rickets
title_short Comparison of Metabolism of Vitamins D(2) and D(3) in Children With Nutritional Rickets
title_sort comparison of metabolism of vitamins d(2) and d(3) in children with nutritional rickets
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153403/
https://www.ncbi.nlm.nih.gov/pubmed/20499377
http://dx.doi.org/10.1002/jbmr.99
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