Cargando…

PARP regulates nonhomologous end joining through retention of Ku at double-strand breaks

Poly adenosine diphosphate (ADP)–ribosylation (PARylation) by poly ADP-ribose (PAR) polymerases (PARPs) is an early response to DNA double-strand breaks (DSBs). In this paper, we exploit Dictyostelium discoideum to uncover a novel role for PARylation in regulating nonhomologous end joining (NHEJ). P...

Descripción completa

Detalles Bibliográficos
Autores principales:	Couto, C. Anne-Marie, Wang, Hong-Yu, Green, Joanna C.A., Kiely, Rhian, Siddaway, Robert, Borer, Christine, Pears, Catherine J., Lakin, Nicholas D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2011
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153639/ https://www.ncbi.nlm.nih.gov/pubmed/21807880 http://dx.doi.org/10.1083/jcb.201012132

Ejemplares similares

Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11
por: Di Virgilio, Michela, et al.
Publicado: (2005)

Smarcal1 promotes double-strand-break repair by nonhomologous end-joining
por: Keka, Islam Shamima, et al.
Publicado: (2015)

PARP retains Ku at double-strand breaks
por: Short, Ben
Publicado: (2011)

Efficient processing of abasic sites by bacterial nonhomologous end-joining Ku proteins
por: de Ory, Ana, et al.
Publicado: (2014)

Bridging of double-stranded breaks by the nonhomologous end-joining ligation complex is modulated by DNA end chemistry
por: Reid, Dylan A., et al.
Publicado: (2017)

Hierarchy of nonhomologous end-joining, single-strand annealing and gene conversion at site-directed DNA double-strand breaks
por: Mansour, Wael Y., et al.
Publicado: (2008)

CRISPR/Cas9-Induced Double-Strand Break Repair in Arabidopsis Nonhomologous End-Joining Mutants
por: Shen, Hexi, et al.
Publicado: (2016)

Hyperactivation of PARP Triggers Nonhomologous End-Joining in Repair-Deficient Mouse Fibroblasts
por: Gassman, Natalie R., et al.
Publicado: (2012)

TDP1 suppresses mis-joining of radiomimetic DNA double-strand breaks and cooperates with Artemis to promote optimal nonhomologous end joining
por: Kawale, Ajinkya S, et al.
Publicado: (2018)

Inhibition of Proteasomal Degradation of Rpn4 Impairs Nonhomologous End-Joining Repair of DNA Double-Strand Breaks
por: Ju, Donghong, et al.
Publicado: (2010)

PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways
por: Beck, Carole, et al.
Publicado: (2014)

Analysis of diverse double-strand break synapsis with Polλ reveals basis for unique substrate specificity in nonhomologous end-joining
por: Kaminski, Andrea M., et al.
Publicado: (2022)

SMYD2 inhibition–mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity
por: Tang, Ming, et al.
Publicado: (2023)

The end-joining factor Ku acts in the end-resection of double strand break-free arrested replication forks
por: Teixeira-Silva, Ana, et al.
Publicado: (2017)

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
por: Chapman, J. Ross, et al.
Publicado: (2013)

RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
por: Chapman, J. Ross, et al.
Publicado: (2021)

Ku70 Functions in Addition to Nonhomologous End Joining in Pancreatic β-Cells: A Connection to β-Catenin Regulation
por: Tavana, Omid, et al.
Publicado: (2013)

Human RECQ1 Interacts with Ku70/80 and Modulates DNA End-Joining of Double-Strand Breaks
por: Parvathaneni, Swetha, et al.
Publicado: (2013)

Nonhomologous DNA End Joining in Cell-Free Extracts
por: Sharma, Sheetal, et al.
Publicado: (2010)

SFPQ•NONO and XLF function separately and together to promote DNA double-strand break repair via canonical nonhomologous end joining
por: Jaafar, Lahcen, et al.
Publicado: (2017)

Evidence for an inositol hexakisphosphate-dependent role for Ku in mammalian nonhomologous end joining that is independent of its role in the DNA-dependent protein kinase
por: Cheung, Joyce C.Y., et al.
Publicado: (2008)

Bacterial Ligase D preternary-precatalytic complex performs efficient abasic sites processing at double strand breaks during nonhomologous end joining
por: de Ory, Ana, et al.
Publicado: (2019)

PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
por: Wang, Minli, et al.
Publicado: (2006)

Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks
por: Cheng, Qiao, et al.
Publicado: (2011)

Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells
por: Fattah, Farjana, et al.
Publicado: (2010)

The Minimal Bacillus subtilis Nonhomologous End Joining Repair Machinery
por: de Vega, Miguel
Publicado: (2013)

Evolutionary and Comparative Analysis of Bacterial Nonhomologous End Joining Repair
por: Sharda, Mohak, et al.
Publicado: (2020)

Super-resolution imaging identifies PARP1 and the Ku complex acting as DNA double-strand break sensors
por: Yang, Guang, et al.
Publicado: (2018)

Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease- and ionizing radiation-induced DNA double-strand breaks
por: Schulte-Uentrop, Leonie, et al.
Publicado: (2008)

A noncatalytic function of the ligation complex during nonhomologous end joining
por: Cottarel, Jessica, et al.
Publicado: (2013)

Cooperative Assembly of a Protein-DNA Filament for Nonhomologous End Joining
por: Tsai, Chun J., et al.
Publicado: (2013)

Reconstitution of Mycobacterium marinum Nonhomologous DNA End Joining Pathway in Leishmania
por: Zhang, Wen-Wei, et al.
Publicado: (2022)

The alternative end-joining pathway for repair of DNA double-strand breaks requires PARP1 but is not dependent upon microhomologies
por: Mansour, Wael Y., et al.
Publicado: (2010)

Resolution of complex ends by Nonhomologous end joining - better to be lucky than good?
por: Strande, Natasha Tiffany, et al.
Publicado: (2012)

PAXX promotes KU accumulation at DNA breaks and is essential for end-joining in XLF-deficient mice
por: Liu, Xiangyu, et al.
Publicado: (2017)

LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining
por: Lawrence, Katherine S., et al.
Publicado: (2016)

Involvement of Artemis in nonhomologous end-joining during immunoglobulin class switch recombination
por: Du, Likun, et al.
Publicado: (2008)

Positive selection on the nonhomologous end-joining factor Cernunnos-XLF in the human lineage
por: Pavlicek, Adam, et al.
Publicado: (2006)

Coincident In Vitro Analysis of DNA-PK-Dependent and -Independent Nonhomologous End Joining
por: Hendrickson, Cynthia L., et al.
Publicado: (2010)

A Process of Resection-Dependent Nonhomologous End Joining Involving the Goddess Artemis
por: Löbrich, Markus, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_bifq5pdp5jggi4h91keuc5hv8g