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Fertility, developmental toxicity and teratogenicity in albino rats treated with methanol sub-fraction of Carica papaya seeds

OBJECTIVE: To evaluate the status of fertility, developmental stages during gestation and teratological changes, if any, following oral administration of methanol sub-fraction (MSF) of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rats. MATERIALS AND...

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Autores principales: Shrivastava, S., Ansari, A.S., Lohiya, N.K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153705/
https://www.ncbi.nlm.nih.gov/pubmed/21844997
http://dx.doi.org/10.4103/0253-7613.83113
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author Shrivastava, S.
Ansari, A.S.
Lohiya, N.K.
author_facet Shrivastava, S.
Ansari, A.S.
Lohiya, N.K.
author_sort Shrivastava, S.
collection PubMed
description OBJECTIVE: To evaluate the status of fertility, developmental stages during gestation and teratological changes, if any, following oral administration of methanol sub-fraction (MSF) of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rats. MATERIALS AND METHODS: The MSF was administered at the doses of 50 mg contraceptive dose (CD), 100 mg (2× CD), 250 mg (5× CD) and 500 mg (10× CD)/kg body wt/day along with vehicle-treated control using 10 male and 20 female Wistar rats in each group. Necropsies were performed one day before the expected parturition. Status of gravid/non-gravid uterus, the number of corpora lutea in the ovary, implantation status, fetal wellbeing, fetal resorption, fetal body weight, external, visceral and skeletal malformations were recorded. RESULTS: Pregnancies were recorded in vehicle-treated control animals and in the animals treated with 50 mg/kg body wt/day. The animals treated with 2× CD, 5× CD and 10× CD did not get pregnant. The fetuses and the status of the ovary, uterus and implantation, fetal body weight, soft tissues and skeletal structures were recorded normal. Data were comparable to those of control. CONCLUSION: The results suggest that the test substance had no developmental toxicity and teratogenicity which could affect pregnancy, implantation and gestation.
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spelling pubmed-31537052011-08-15 Fertility, developmental toxicity and teratogenicity in albino rats treated with methanol sub-fraction of Carica papaya seeds Shrivastava, S. Ansari, A.S. Lohiya, N.K. Indian J Pharmacol Research Article OBJECTIVE: To evaluate the status of fertility, developmental stages during gestation and teratological changes, if any, following oral administration of methanol sub-fraction (MSF) of the benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rats. MATERIALS AND METHODS: The MSF was administered at the doses of 50 mg contraceptive dose (CD), 100 mg (2× CD), 250 mg (5× CD) and 500 mg (10× CD)/kg body wt/day along with vehicle-treated control using 10 male and 20 female Wistar rats in each group. Necropsies were performed one day before the expected parturition. Status of gravid/non-gravid uterus, the number of corpora lutea in the ovary, implantation status, fetal wellbeing, fetal resorption, fetal body weight, external, visceral and skeletal malformations were recorded. RESULTS: Pregnancies were recorded in vehicle-treated control animals and in the animals treated with 50 mg/kg body wt/day. The animals treated with 2× CD, 5× CD and 10× CD did not get pregnant. The fetuses and the status of the ovary, uterus and implantation, fetal body weight, soft tissues and skeletal structures were recorded normal. Data were comparable to those of control. CONCLUSION: The results suggest that the test substance had no developmental toxicity and teratogenicity which could affect pregnancy, implantation and gestation. Medknow Publications 2011 /pmc/articles/PMC3153705/ /pubmed/21844997 http://dx.doi.org/10.4103/0253-7613.83113 Text en © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Shrivastava, S.
Ansari, A.S.
Lohiya, N.K.
Fertility, developmental toxicity and teratogenicity in albino rats treated with methanol sub-fraction of Carica papaya seeds
title Fertility, developmental toxicity and teratogenicity in albino rats treated with methanol sub-fraction of Carica papaya seeds
title_full Fertility, developmental toxicity and teratogenicity in albino rats treated with methanol sub-fraction of Carica papaya seeds
title_fullStr Fertility, developmental toxicity and teratogenicity in albino rats treated with methanol sub-fraction of Carica papaya seeds
title_full_unstemmed Fertility, developmental toxicity and teratogenicity in albino rats treated with methanol sub-fraction of Carica papaya seeds
title_short Fertility, developmental toxicity and teratogenicity in albino rats treated with methanol sub-fraction of Carica papaya seeds
title_sort fertility, developmental toxicity and teratogenicity in albino rats treated with methanol sub-fraction of carica papaya seeds
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153705/
https://www.ncbi.nlm.nih.gov/pubmed/21844997
http://dx.doi.org/10.4103/0253-7613.83113
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AT lohiyank fertilitydevelopmentaltoxicityandteratogenicityinalbinoratstreatedwithmethanolsubfractionofcaricapapayaseeds