Cargando…
A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma
Arformoterol, a long-acting beta-2 agonist, has a rapid onset and long duration of action. Its role as rescue medication in acute asthma attack is undetermined. To compare the efficacy and tolerability of arformoterol with salbutamol nebulization, a study was conducted among 50 patients with acute n...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153715/ https://www.ncbi.nlm.nih.gov/pubmed/21845007 http://dx.doi.org/10.4103/0253-7613.83123 |
_version_ | 1782209927593328640 |
---|---|
author | Das, Sibes K. Biswas, Indranil Bandyopadhyay, Arun K. Bairagya, Tapan D. Bhattacharya, Somnath |
author_facet | Das, Sibes K. Biswas, Indranil Bandyopadhyay, Arun K. Bairagya, Tapan D. Bhattacharya, Somnath |
author_sort | Das, Sibes K. |
collection | PubMed |
description | Arformoterol, a long-acting beta-2 agonist, has a rapid onset and long duration of action. Its role as rescue medication in acute asthma attack is undetermined. To compare the efficacy and tolerability of arformoterol with salbutamol nebulization, a study was conducted among 50 patients with acute non-severe asthma. Patients were randomly assigned to group 1 (n = 25) and group 2 (n = 25) who received three doses of salbutamol and arformoterol nebulization, respectively, at 20-min intervals. The peak expiratory flow rate (PEFR) was measured at the baseline and 5 min after each dose. The demographics and baseline characteristics were comparable between the two groups. The mean PEFR significantly increased in both these groups when compared with the baseline. The increases in the PEFR in two groups were similar after the third dose. The adverse effects in both these groups were minor. Arformoterol was as effective and safe as salbutamol in acute non-severe asthma. |
format | Online Article Text |
id | pubmed-3153715 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-31537152011-08-15 A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma Das, Sibes K. Biswas, Indranil Bandyopadhyay, Arun K. Bairagya, Tapan D. Bhattacharya, Somnath Indian J Pharmacol Short Communication Arformoterol, a long-acting beta-2 agonist, has a rapid onset and long duration of action. Its role as rescue medication in acute asthma attack is undetermined. To compare the efficacy and tolerability of arformoterol with salbutamol nebulization, a study was conducted among 50 patients with acute non-severe asthma. Patients were randomly assigned to group 1 (n = 25) and group 2 (n = 25) who received three doses of salbutamol and arformoterol nebulization, respectively, at 20-min intervals. The peak expiratory flow rate (PEFR) was measured at the baseline and 5 min after each dose. The demographics and baseline characteristics were comparable between the two groups. The mean PEFR significantly increased in both these groups when compared with the baseline. The increases in the PEFR in two groups were similar after the third dose. The adverse effects in both these groups were minor. Arformoterol was as effective and safe as salbutamol in acute non-severe asthma. Medknow Publications 2011 /pmc/articles/PMC3153715/ /pubmed/21845007 http://dx.doi.org/10.4103/0253-7613.83123 Text en © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Das, Sibes K. Biswas, Indranil Bandyopadhyay, Arun K. Bairagya, Tapan D. Bhattacharya, Somnath A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma |
title | A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma |
title_full | A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma |
title_fullStr | A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma |
title_full_unstemmed | A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma |
title_short | A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma |
title_sort | comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153715/ https://www.ncbi.nlm.nih.gov/pubmed/21845007 http://dx.doi.org/10.4103/0253-7613.83123 |
work_keys_str_mv | AT dassibesk acomparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma AT biswasindranil acomparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma AT bandyopadhyayarunk acomparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma AT bairagyatapand acomparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma AT bhattacharyasomnath acomparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma AT dassibesk comparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma AT biswasindranil comparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma AT bandyopadhyayarunk comparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma AT bairagyatapand comparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma AT bhattacharyasomnath comparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma |