Cargando…

A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma

Arformoterol, a long-acting beta-2 agonist, has a rapid onset and long duration of action. Its role as rescue medication in acute asthma attack is undetermined. To compare the efficacy and tolerability of arformoterol with salbutamol nebulization, a study was conducted among 50 patients with acute n...

Descripción completa

Detalles Bibliográficos
Autores principales: Das, Sibes K., Biswas, Indranil, Bandyopadhyay, Arun K., Bairagya, Tapan D., Bhattacharya, Somnath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153715/
https://www.ncbi.nlm.nih.gov/pubmed/21845007
http://dx.doi.org/10.4103/0253-7613.83123
_version_ 1782209927593328640
author Das, Sibes K.
Biswas, Indranil
Bandyopadhyay, Arun K.
Bairagya, Tapan D.
Bhattacharya, Somnath
author_facet Das, Sibes K.
Biswas, Indranil
Bandyopadhyay, Arun K.
Bairagya, Tapan D.
Bhattacharya, Somnath
author_sort Das, Sibes K.
collection PubMed
description Arformoterol, a long-acting beta-2 agonist, has a rapid onset and long duration of action. Its role as rescue medication in acute asthma attack is undetermined. To compare the efficacy and tolerability of arformoterol with salbutamol nebulization, a study was conducted among 50 patients with acute non-severe asthma. Patients were randomly assigned to group 1 (n = 25) and group 2 (n = 25) who received three doses of salbutamol and arformoterol nebulization, respectively, at 20-min intervals. The peak expiratory flow rate (PEFR) was measured at the baseline and 5 min after each dose. The demographics and baseline characteristics were comparable between the two groups. The mean PEFR significantly increased in both these groups when compared with the baseline. The increases in the PEFR in two groups were similar after the third dose. The adverse effects in both these groups were minor. Arformoterol was as effective and safe as salbutamol in acute non-severe asthma.
format Online
Article
Text
id pubmed-3153715
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher Medknow Publications
record_format MEDLINE/PubMed
spelling pubmed-31537152011-08-15 A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma Das, Sibes K. Biswas, Indranil Bandyopadhyay, Arun K. Bairagya, Tapan D. Bhattacharya, Somnath Indian J Pharmacol Short Communication Arformoterol, a long-acting beta-2 agonist, has a rapid onset and long duration of action. Its role as rescue medication in acute asthma attack is undetermined. To compare the efficacy and tolerability of arformoterol with salbutamol nebulization, a study was conducted among 50 patients with acute non-severe asthma. Patients were randomly assigned to group 1 (n = 25) and group 2 (n = 25) who received three doses of salbutamol and arformoterol nebulization, respectively, at 20-min intervals. The peak expiratory flow rate (PEFR) was measured at the baseline and 5 min after each dose. The demographics and baseline characteristics were comparable between the two groups. The mean PEFR significantly increased in both these groups when compared with the baseline. The increases in the PEFR in two groups were similar after the third dose. The adverse effects in both these groups were minor. Arformoterol was as effective and safe as salbutamol in acute non-severe asthma. Medknow Publications 2011 /pmc/articles/PMC3153715/ /pubmed/21845007 http://dx.doi.org/10.4103/0253-7613.83123 Text en © Indian Journal of Pharmacology http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Das, Sibes K.
Biswas, Indranil
Bandyopadhyay, Arun K.
Bairagya, Tapan D.
Bhattacharya, Somnath
A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma
title A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma
title_full A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma
title_fullStr A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma
title_full_unstemmed A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma
title_short A comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma
title_sort comparative study of efficacy and safety of arformoterol and salbutamol nebulization as rescue therapy in acute non-severe asthma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153715/
https://www.ncbi.nlm.nih.gov/pubmed/21845007
http://dx.doi.org/10.4103/0253-7613.83123
work_keys_str_mv AT dassibesk acomparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma
AT biswasindranil acomparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma
AT bandyopadhyayarunk acomparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma
AT bairagyatapand acomparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma
AT bhattacharyasomnath acomparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma
AT dassibesk comparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma
AT biswasindranil comparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma
AT bandyopadhyayarunk comparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma
AT bairagyatapand comparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma
AT bhattacharyasomnath comparativestudyofefficacyandsafetyofarformoterolandsalbutamolnebulizationasrescuetherapyinacutenonsevereasthma