Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds

A number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the mo...

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Detalles Bibliográficos
Autores principales: Tanabe, Kazuhito, Ito, Takeo, Nishimoto, Sei-ichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE-Hindawi Access to Research 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153922/
https://www.ncbi.nlm.nih.gov/pubmed/21860782
http://dx.doi.org/10.4061/2011/816207
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author Tanabe, Kazuhito
Ito, Takeo
Nishimoto, Sei-ichi
author_facet Tanabe, Kazuhito
Ito, Takeo
Nishimoto, Sei-ichi
author_sort Tanabe, Kazuhito
collection PubMed
description A number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the molecular design of artificial ODNs that are activated by X-irradiation and their applications to regulation of hybridization properties, conformation change, radiation-activated DNAzyme, and decoy molecules.
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spelling pubmed-31539222011-08-22 Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds Tanabe, Kazuhito Ito, Takeo Nishimoto, Sei-ichi J Nucleic Acids Review Article A number of advances have been made in the development of modified oligodeoxynucleotides (ODNs), and chemical or physical properties of which are controlled by external stimuli. These intelligent ODNs are promising for the next generation of gene diagnostics and therapy. This paper focuses on the molecular design of artificial ODNs that are activated by X-irradiation and their applications to regulation of hybridization properties, conformation change, radiation-activated DNAzyme, and decoy molecules. SAGE-Hindawi Access to Research 2011-08-08 /pmc/articles/PMC3153922/ /pubmed/21860782 http://dx.doi.org/10.4061/2011/816207 Text en Copyright © 2011 Kazuhito Tanabe et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Tanabe, Kazuhito
Ito, Takeo
Nishimoto, Sei-ichi
Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
title Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
title_full Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
title_fullStr Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
title_full_unstemmed Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
title_short Radiolytic Reduction Characteristics of Artificial Oligodeoxynucleotides Possessing 2-Oxoalkyl Group or Disulfide Bonds
title_sort radiolytic reduction characteristics of artificial oligodeoxynucleotides possessing 2-oxoalkyl group or disulfide bonds
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153922/
https://www.ncbi.nlm.nih.gov/pubmed/21860782
http://dx.doi.org/10.4061/2011/816207
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AT nishimotoseiichi radiolyticreductioncharacteristicsofartificialoligodeoxynucleotidespossessing2oxoalkylgroupordisulfidebonds

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