Determination of the Loss of Function Complement C4 Exon 29 CT Insertion Using a Novel Paralog-Specific Assay in Healthy UK and Spanish Populations

Genetic variants resulting in non-expression of complement C4A and C4B genes are common in healthy European populations and have shown association with a number of diseases, most notably the autoimmune disease, systemic lupus erythematosus. The most frequent cause of a C4 “null” allele, following th...

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Detalles Bibliográficos
Autores principales: Boteva, Lora, Wu, Yee Ling, Cortes-Hernández, Josefina, Martin, Javier, Vyse, Timothy J., Fernando, Michelle M. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153930/
https://www.ncbi.nlm.nih.gov/pubmed/21857912
http://dx.doi.org/10.1371/journal.pone.0022128

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