Dysregulated LRRK2 Signaling in Response to Endoplasmic Reticulum Stress Leads to Dopaminergic Neuron Degeneration in C. elegans

Mutation of leucine-rich repeat kinase 2 (LRRK2) is the leading genetic cause of Parkinson's Disease (PD), manifested as age-dependent dopaminergic neurodegeneration, but the underlying molecular mechanisms remain unclear. Multiple roles of LRRK2 may contribute to dopaminergic neurodegeneration...

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Detalles Bibliográficos
Autores principales: Yuan, Yiyuan, Cao, Pengxiu, Smith, Mark A., Kramp, Kristopher, Huang, Ying, Hisamoto, Naoki, Matsumoto, Kunihiro, Hatzoglou, Maria, Jin, Hui, Feng, Zhaoyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153934/
https://www.ncbi.nlm.nih.gov/pubmed/21857923
http://dx.doi.org/10.1371/journal.pone.0022354

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153934/
https://www.ncbi.nlm.nih.gov/pubmed/21857923
http://dx.doi.org/10.1371/journal.pone.0022354

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