Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease

Post-mitotic neurons are typically terminally differentiated and in a quiescent status. However, in Alzheimer disease (AD), many neurons display ectopic re-expression of cell cycle-related proteins. Cyclin-dependent kinase 11 (CDK11) mRNA produces a 110-kDa protein (CDK11(p110)) throughout the cell...

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Detalles Bibliográficos
Autores principales: Bajić, Vladan P., Su, Bo, Lee, Hyoung-Gon, Kudo, Wataru, Siedlak, Sandra L., Živković, Lada, Spremo-Potparević, Biljana, Djelic, Ninoslav, Milicevic, Zorana, Singh, Avneet K., Fahmy, Lara M., Wang, Xinglong, Smith, Mark A., Zhu, Xiongwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SP Versita 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3153952/
https://www.ncbi.nlm.nih.gov/pubmed/21461981
http://dx.doi.org/10.2478/s11658-011-0011-2

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