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Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders
The mammalian target of rapamycin (mTOR) and its associated cell signaling pathways have garnered significant attention for their roles in cell biology and oncology. Interestingly,the explosion of information in this field has linked mTOR to neurological diseases with promising initial studies. mTOR...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154047/ https://www.ncbi.nlm.nih.gov/pubmed/21307646 http://dx.doi.org/10.4161/oxim.3.6.14787 |
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author | Chong, Zhao Zhong Shang, Yan Chen Zhang, Lijie Wang, Shaohui Maiese, Kenneth |
author_facet | Chong, Zhao Zhong Shang, Yan Chen Zhang, Lijie Wang, Shaohui Maiese, Kenneth |
author_sort | Chong, Zhao Zhong |
collection | PubMed |
description | The mammalian target of rapamycin (mTOR) and its associated cell signaling pathways have garnered significant attention for their roles in cell biology and oncology. Interestingly,the explosion of information in this field has linked mTOR to neurological diseases with promising initial studies. mTOR, a 289 kDa serine/threonine protein kinase, plays an important role in cell growth and proliferation and is activated through phosphorylation in response to growth factors, mitogens and hormones. Growth factors, amino acids, cellular nutrients and oxygen deficiency can downregulate mTOR activity. The function of mTOR signaling is mediated primarily through two mTOR complexes: mTORC1 and mTORC2. mTORC1 initiates cap-dependent protein translation, a rate-limiting step of protein synthesis, through the phosphorylation of the targets eukaryotic initiation factor 4E-binding protein 1 (4EBP1) and p70 ribosomal S6 kinase (p70S6K). In contrast, mTORC2 regulates development of the cytoskeleton and also controls cell survival. Although closely tied to tumorigenesis, mTOR and the downstream signaling pathways are significantly involved in the central nervous system (CNS) with synaptic plasticity, memory retention, neuroendocrine regulation associated with food intake and puberty and modulation of neuronal repair following injury. The signaling pathways of mTOR also are believed to be a significant component in a number of neurological diseases, such as Alzheimer disease, Parkinson disease and Huntington disease, tuberous sclerosis, neurofibromatosis, fragile X syndrome, epilepsy, traumatic brain injury and ischemic stroke. Here we describe the role of mTOR in the CNS and illustrate the potential for new strategies directed against neurological disorders. |
format | Online Article Text |
id | pubmed-3154047 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-31540472011-08-29 Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders Chong, Zhao Zhong Shang, Yan Chen Zhang, Lijie Wang, Shaohui Maiese, Kenneth Oxid Med Cell Longev Review The mammalian target of rapamycin (mTOR) and its associated cell signaling pathways have garnered significant attention for their roles in cell biology and oncology. Interestingly,the explosion of information in this field has linked mTOR to neurological diseases with promising initial studies. mTOR, a 289 kDa serine/threonine protein kinase, plays an important role in cell growth and proliferation and is activated through phosphorylation in response to growth factors, mitogens and hormones. Growth factors, amino acids, cellular nutrients and oxygen deficiency can downregulate mTOR activity. The function of mTOR signaling is mediated primarily through two mTOR complexes: mTORC1 and mTORC2. mTORC1 initiates cap-dependent protein translation, a rate-limiting step of protein synthesis, through the phosphorylation of the targets eukaryotic initiation factor 4E-binding protein 1 (4EBP1) and p70 ribosomal S6 kinase (p70S6K). In contrast, mTORC2 regulates development of the cytoskeleton and also controls cell survival. Although closely tied to tumorigenesis, mTOR and the downstream signaling pathways are significantly involved in the central nervous system (CNS) with synaptic plasticity, memory retention, neuroendocrine regulation associated with food intake and puberty and modulation of neuronal repair following injury. The signaling pathways of mTOR also are believed to be a significant component in a number of neurological diseases, such as Alzheimer disease, Parkinson disease and Huntington disease, tuberous sclerosis, neurofibromatosis, fragile X syndrome, epilepsy, traumatic brain injury and ischemic stroke. Here we describe the role of mTOR in the CNS and illustrate the potential for new strategies directed against neurological disorders. Hindawi Publishing Corporation 2010 /pmc/articles/PMC3154047/ /pubmed/21307646 http://dx.doi.org/10.4161/oxim.3.6.14787 Text en Copyright © 2010 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Chong, Zhao Zhong Shang, Yan Chen Zhang, Lijie Wang, Shaohui Maiese, Kenneth Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders |
title | Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders |
title_full | Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders |
title_fullStr | Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders |
title_full_unstemmed | Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders |
title_short | Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders |
title_sort | mammalian target of rapamycin: hitting the bull's-eye for neurological disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154047/ https://www.ncbi.nlm.nih.gov/pubmed/21307646 http://dx.doi.org/10.4161/oxim.3.6.14787 |
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