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Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery

BACKGROUND: AMH's reported stability during periods of hormonal change makes it a practical tool in assessing ovarian reserve. However, AMH declines with age and age-specific cut-offs remain to be established in women with proven fertility. This study aims to determine age-specific ranges of AM...

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Autores principales: Weghofer, Andrea, Dietrich, Wolf, Ortner, Iris, Bieglmayer, Christian, Barad, David, Gleicher, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154148/
https://www.ncbi.nlm.nih.gov/pubmed/21777422
http://dx.doi.org/10.1186/1477-7827-9-98
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author Weghofer, Andrea
Dietrich, Wolf
Ortner, Iris
Bieglmayer, Christian
Barad, David
Gleicher, Norbert
author_facet Weghofer, Andrea
Dietrich, Wolf
Ortner, Iris
Bieglmayer, Christian
Barad, David
Gleicher, Norbert
author_sort Weghofer, Andrea
collection PubMed
description BACKGROUND: AMH's reported stability during periods of hormonal change makes it a practical tool in assessing ovarian reserve. However, AMH declines with age and age-specific cut-offs remain to be established in women with proven fertility. This study aims to determine age-specific ranges of AMH in women with proven fertility. METHODS: Two hundred-ten fertile women, aged 18-40 years, were prospectively recruited for AMH measurements within 14 days after delivery and age stratified into 3 groups (18-30, 31-36 and 37-40 years). Eligibility required spontaneous conception within a maximal period of six months. Autoimmune diseases, chemotherapy, radiation, ovarian surgery and polycystic ovary syndrome precluded inclusion. RESULTS: 95% confidence intervals of AMH declined with advancing female age from 0.9-1.1 to 0.6-0.9 and 0.2-0.4 ng/mL (P < 0.001). AMH levels were not statistically associated with day of blood draw after delivery or pregnancy characteristics. Neither were they predictive of resumption of menses. They, however, at all ages were lower than reported in the literature for infertile patients. CONCLUSIONS: Like infertile populations, fertile women demonstrate declining AMH with advancing age. Uniformly lower levels than in infertile women suggest that AMH levels do not appear as stable under all hormonal influences as previously reported.
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spelling pubmed-31541482011-08-11 Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery Weghofer, Andrea Dietrich, Wolf Ortner, Iris Bieglmayer, Christian Barad, David Gleicher, Norbert Reprod Biol Endocrinol Research BACKGROUND: AMH's reported stability during periods of hormonal change makes it a practical tool in assessing ovarian reserve. However, AMH declines with age and age-specific cut-offs remain to be established in women with proven fertility. This study aims to determine age-specific ranges of AMH in women with proven fertility. METHODS: Two hundred-ten fertile women, aged 18-40 years, were prospectively recruited for AMH measurements within 14 days after delivery and age stratified into 3 groups (18-30, 31-36 and 37-40 years). Eligibility required spontaneous conception within a maximal period of six months. Autoimmune diseases, chemotherapy, radiation, ovarian surgery and polycystic ovary syndrome precluded inclusion. RESULTS: 95% confidence intervals of AMH declined with advancing female age from 0.9-1.1 to 0.6-0.9 and 0.2-0.4 ng/mL (P < 0.001). AMH levels were not statistically associated with day of blood draw after delivery or pregnancy characteristics. Neither were they predictive of resumption of menses. They, however, at all ages were lower than reported in the literature for infertile patients. CONCLUSIONS: Like infertile populations, fertile women demonstrate declining AMH with advancing age. Uniformly lower levels than in infertile women suggest that AMH levels do not appear as stable under all hormonal influences as previously reported. BioMed Central 2011-07-21 /pmc/articles/PMC3154148/ /pubmed/21777422 http://dx.doi.org/10.1186/1477-7827-9-98 Text en Copyright ©2011 Weghofer et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Weghofer, Andrea
Dietrich, Wolf
Ortner, Iris
Bieglmayer, Christian
Barad, David
Gleicher, Norbert
Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery
title Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery
title_full Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery
title_fullStr Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery
title_full_unstemmed Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery
title_short Anti-Mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery
title_sort anti-mullerian hormone levels decline under hormonal suppression: a prospective analysis in fertile women after delivery
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154148/
https://www.ncbi.nlm.nih.gov/pubmed/21777422
http://dx.doi.org/10.1186/1477-7827-9-98
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