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Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study
BACKGROUND: Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. We tried to assess the effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency anemia in children. METHODS: This was a case control st...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154149/ https://www.ncbi.nlm.nih.gov/pubmed/21771327 http://dx.doi.org/10.1186/1824-7288-37-34 |
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author | Sanad, Mohammed Osman, Mohammed Gharib, Amal |
author_facet | Sanad, Mohammed Osman, Mohammed Gharib, Amal |
author_sort | Sanad, Mohammed |
collection | PubMed |
description | BACKGROUND: Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. We tried to assess the effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency anemia in children. METHODS: This was a case control study included 70 children with iron deficiency anemia "IDA" (35 obese and 35 non-obese) and 30 healthy non-obese children with comparable age and sex(control group). Parameters of iron status (Serum iron, ferritin, transferrin, total iron binding capacity and transferrin saturation) and serum hepcidin levels were assessed initially and after 3 months of oral iron therapy for IDA. RESULTS: Compared to the control group, serum hepcidin was significantly lower in non-obese children with IDA(p < 0.01) and significantly higher in obese children with IDA (p < 0.01). Hepcidin increased significantly in non-obese children with IDA after 3 months of iron therapy (P < 0.01). On the other hand, obese children showed non-significant change in hepcidin level after iron therapy (p > 0.05). Although hepcidin showed significant positive correlations with Hb, serum iron and transferrin saturation in non-obese children with IDA, it showed significant negative correlations with Hb, serum iron and transferrin saturation in obese children with IDA (P < 0.05). CONCLUSIONS: Obesity increased hepcidin levels and was associated with diminished response to oral iron therapy in childhood iron deficiency anemia. |
format | Online Article Text |
id | pubmed-3154149 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31541492011-08-11 Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study Sanad, Mohammed Osman, Mohammed Gharib, Amal Ital J Pediatr Research BACKGROUND: Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. We tried to assess the effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency anemia in children. METHODS: This was a case control study included 70 children with iron deficiency anemia "IDA" (35 obese and 35 non-obese) and 30 healthy non-obese children with comparable age and sex(control group). Parameters of iron status (Serum iron, ferritin, transferrin, total iron binding capacity and transferrin saturation) and serum hepcidin levels were assessed initially and after 3 months of oral iron therapy for IDA. RESULTS: Compared to the control group, serum hepcidin was significantly lower in non-obese children with IDA(p < 0.01) and significantly higher in obese children with IDA (p < 0.01). Hepcidin increased significantly in non-obese children with IDA after 3 months of iron therapy (P < 0.01). On the other hand, obese children showed non-significant change in hepcidin level after iron therapy (p > 0.05). Although hepcidin showed significant positive correlations with Hb, serum iron and transferrin saturation in non-obese children with IDA, it showed significant negative correlations with Hb, serum iron and transferrin saturation in obese children with IDA (P < 0.05). CONCLUSIONS: Obesity increased hepcidin levels and was associated with diminished response to oral iron therapy in childhood iron deficiency anemia. BioMed Central 2011-07-19 /pmc/articles/PMC3154149/ /pubmed/21771327 http://dx.doi.org/10.1186/1824-7288-37-34 Text en Copyright ©2011 Sanad et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Sanad, Mohammed Osman, Mohammed Gharib, Amal Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study |
title | Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study |
title_full | Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study |
title_fullStr | Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study |
title_full_unstemmed | Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study |
title_short | Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study |
title_sort | obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: a case control study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154149/ https://www.ncbi.nlm.nih.gov/pubmed/21771327 http://dx.doi.org/10.1186/1824-7288-37-34 |
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