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Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study

BACKGROUND: Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. We tried to assess the effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency anemia in children. METHODS: This was a case control st...

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Autores principales: Sanad, Mohammed, Osman, Mohammed, Gharib, Amal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154149/
https://www.ncbi.nlm.nih.gov/pubmed/21771327
http://dx.doi.org/10.1186/1824-7288-37-34
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author Sanad, Mohammed
Osman, Mohammed
Gharib, Amal
author_facet Sanad, Mohammed
Osman, Mohammed
Gharib, Amal
author_sort Sanad, Mohammed
collection PubMed
description BACKGROUND: Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. We tried to assess the effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency anemia in children. METHODS: This was a case control study included 70 children with iron deficiency anemia "IDA" (35 obese and 35 non-obese) and 30 healthy non-obese children with comparable age and sex(control group). Parameters of iron status (Serum iron, ferritin, transferrin, total iron binding capacity and transferrin saturation) and serum hepcidin levels were assessed initially and after 3 months of oral iron therapy for IDA. RESULTS: Compared to the control group, serum hepcidin was significantly lower in non-obese children with IDA(p < 0.01) and significantly higher in obese children with IDA (p < 0.01). Hepcidin increased significantly in non-obese children with IDA after 3 months of iron therapy (P < 0.01). On the other hand, obese children showed non-significant change in hepcidin level after iron therapy (p > 0.05). Although hepcidin showed significant positive correlations with Hb, serum iron and transferrin saturation in non-obese children with IDA, it showed significant negative correlations with Hb, serum iron and transferrin saturation in obese children with IDA (P < 0.05). CONCLUSIONS: Obesity increased hepcidin levels and was associated with diminished response to oral iron therapy in childhood iron deficiency anemia.
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spelling pubmed-31541492011-08-11 Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study Sanad, Mohammed Osman, Mohammed Gharib, Amal Ital J Pediatr Research BACKGROUND: Recently, hepcidin expression in adipose tissue has been described and shown to be increased in patients with severe obesity. We tried to assess the effect of obesity on hepcidin serum levels and treatment outcome of iron deficiency anemia in children. METHODS: This was a case control study included 70 children with iron deficiency anemia "IDA" (35 obese and 35 non-obese) and 30 healthy non-obese children with comparable age and sex(control group). Parameters of iron status (Serum iron, ferritin, transferrin, total iron binding capacity and transferrin saturation) and serum hepcidin levels were assessed initially and after 3 months of oral iron therapy for IDA. RESULTS: Compared to the control group, serum hepcidin was significantly lower in non-obese children with IDA(p < 0.01) and significantly higher in obese children with IDA (p < 0.01). Hepcidin increased significantly in non-obese children with IDA after 3 months of iron therapy (P < 0.01). On the other hand, obese children showed non-significant change in hepcidin level after iron therapy (p > 0.05). Although hepcidin showed significant positive correlations with Hb, serum iron and transferrin saturation in non-obese children with IDA, it showed significant negative correlations with Hb, serum iron and transferrin saturation in obese children with IDA (P < 0.05). CONCLUSIONS: Obesity increased hepcidin levels and was associated with diminished response to oral iron therapy in childhood iron deficiency anemia. BioMed Central 2011-07-19 /pmc/articles/PMC3154149/ /pubmed/21771327 http://dx.doi.org/10.1186/1824-7288-37-34 Text en Copyright ©2011 Sanad et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Sanad, Mohammed
Osman, Mohammed
Gharib, Amal
Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study
title Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study
title_full Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study
title_fullStr Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study
title_full_unstemmed Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study
title_short Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study
title_sort obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: a case control study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154149/
https://www.ncbi.nlm.nih.gov/pubmed/21771327
http://dx.doi.org/10.1186/1824-7288-37-34
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