Cargando…

Evolving hard problems: Generating human genetics datasets with a complex etiology

BACKGROUND: A goal of human genetics is to discover genetic factors that influence individuals' susceptibility to common diseases. Most common diseases are thought to result from the joint failure of two or more interacting components instead of single component failures. This greatly complicat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Himmelstein, Daniel S, Greene, Casey S, Moore, Jason H
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Methodology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154150/ https://www.ncbi.nlm.nih.gov/pubmed/21736753 http://dx.doi.org/10.1186/1756-0381-4-21

Ejemplares similares

Erratum to: Evolving hard problems: generating human genetics datasets with a complex etiology
por: Himmelstein, Daniel S., et al.
Publicado: (2016)

Testing multiple hypotheses through IMP weighted FDR based on a genetic functional network with application to a new zebrafish transcriptome study
por: Gui, Jiang, et al.
Publicado: (2015)

Spatially Uniform ReliefF (SURF) for computationally-efficient filtering of gene-gene interactions
por: Greene, Casey S, et al.
Publicado: (2009)

Identification of genetic interaction networks via an evolutionary algorithm evolved Bayesian network
por: Li, Ruowang, et al.
Publicado: (2016)

Nonpher: computational method for design of hard-to-synthesize structures
por: Voršilák, Milan, et al.
Publicado: (2017)

MetaCRS: unsupervised clustering of contigs with the recursive strategy of reducing metagenomic dataset’s complexity
por: Jiang, Zhongjun, et al.
Publicado: (2022)

Using principal component analysis to reduce complex datasets produced by robotic technology in healthy participants
por: Wood, Michael D., et al.
Publicado: (2018)

Benchmark datasets of immune receptor-epitope structural complexes
por: Mahajan, Swapnil, et al.
Publicado: (2019)

Generation of Gene Ontology benchmark datasets with various types of positive signal
por: Törönen, Petri, et al.
Publicado: (2009)

Improving machine learning reproducibility in genetic association studies with proportional instance cross validation (PICV)
por: Piette, Elizabeth R., et al.
Publicado: (2018)

A ligation and restriction enzyme independent cloning technique: an alternative to conventional methods for cloning hard-to-clone gene segments in the influenza reverse genetics system
por: Bhat, Sushant, et al.
Publicado: (2020)

“We are not hard to reach, but we may find it hard to trust” …. Involving and engaging ‘seldom listened to’ community voices in clinical translational health research: a social innovation approach
por: Islam, Safina, et al.
Publicado: (2021)

Diverse convergent evidence in the genetic analysis of complex disease: coordinating omic, informatic, and experimental evidence to better identify and validate risk factors
por: Ciesielski, Timothy H, et al.
Publicado: (2014)

GAMETES: a fast, direct algorithm for generating pure, strict, epistatic models with random architectures
por: Urbanowicz, Ryan J, et al.
Publicado: (2012)

Developing a Comprehensive Database Management System for Organization and Evaluation of Mammography Datasets
por: Wu, Yirong, et al.
Publicado: (2014)

barCoder: a tool to generate unique, orthogonal genetic tags for qPCR detection
por: Bernhards, Casey B., et al.
Publicado: (2021)

Evolutionary triangulation: informing genetic association studies with evolutionary evidence
por: Huang, Minjun, et al.
Publicado: (2016)

Towards interoperable and reproducible QSAR analyses: Exchange of datasets
por: Spjuth, Ola, et al.
Publicado: (2010)

Exhaustive expansion: A novel technique for analyzing complex data generated by higher-order polychromatic flow cytometry experiments
por: Siebert, Janet C, et al.
Publicado: (2010)

Identifying time-delayed gene regulatory networks via an evolvable hierarchical recurrent neural network
por: Kordmahalleh, Mina Moradi, et al.
Publicado: (2017)

Expanding a database-derived biomedical knowledge graph via multi-relation extraction from biomedical abstracts
por: Nicholson, David N., et al.
Publicado: (2022)

Clustering evolving proteins into homologous families
por: Chan, Cheong Xin, et al.
Publicado: (2013)

Multifactor dimensionality reduction for graphics processing units enables genome-wide testing of epistasis in sporadic ALS
por: Greene, Casey S., et al.
Publicado: (2010)

Combination of novel and public RNA-seq datasets to generate an mRNA expression atlas for the domestic chicken
por: Bush, Stephen J., et al.
Publicado: (2018)

Periodicity Detection Method for Small-Sample Time Series Datasets
por: Tominaga, Daisuke
Publicado: (2010)

Grid-based stochastic search for hierarchical gene-gene interactions in population-based genetic studies of common human diseases
por: Moore, Jason H., et al.
Publicado: (2017)

A computational model for sex-specific genetic architecture of complex traits in humans: Implications for mapping pain sensitivity
por: Wang, Chenguang, et al.
Publicado: (2008)

The small trial problem
por: Raymond, Jean, et al.
Publicado: (2023)

Uncovering correlated variability in epigenomic datasets using the Karhunen-Loeve transform
por: Madrigal, Pedro, et al.
Publicado: (2015)

Data sharing in clinical trials – practical guidance on anonymising trial datasets
por: Keerie, Catriona, et al.
Publicado: (2018)

Utilization of Google enterprise tools to georeference survey data among hard-to-reach groups: strategic application in international settings
por: Beletsky, Leo, et al.
Publicado: (2016)

Identification of Differentially Evolved Genes: An Alternative Approach to Detection of Accelerated Molecular Evolution from Genome-Wide Comparative Data
por: Kim, Kyu-Won, et al.
Publicado: (2013)

PrestOMIC, an open source application for dissemination of proteomic datasets by individual laboratories
por: Howes, Charles G, et al.
Publicado: (2007)

Phenoplant: a web resource for the exploration of large chlorophyll fluorescence image datasets
por: Rousseau, Céline, et al.
Publicado: (2015)

Mixed methods in pre-hospital research: understanding complex clinical problems
por: Whitley, Gregory Adam, et al.
Publicado: (2020)

Standardized collection of MNase-seq experiments enables unbiased dataset comparisons
por: Rizzo, Jason M, et al.
Publicado: (2012)

On the visualization of universal degeneracy in the IMRT problem
por: Alber, Markus L, et al.
Publicado: (2006)

Methodology for Constructing Problem Definitions in Bioinformatics
por: Hauth, Amy M., et al.
Publicado: (2008)

Generation of a monoclonal antibody against the glycosylphosphatidylinositol-linked protein Rae-1 using genetically engineered tumor cells
por: Hu, Jiemiao, et al.
Publicado: (2014)

MITOSCISSOR: A Useful Tool for Auto-Assembly of Mitogenomic Datasets in the Evolutionary Analysis of Fishes
por: Sun, Zheng, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_2185200cdcebchds8gn9pjgpie