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Analysis of MMP2 promoter polymorphisms in childhood obesity
BACKGROUND: Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of childhood obesity in a New Zealand population. FINDI...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154167/ https://www.ncbi.nlm.nih.gov/pubmed/21777433 http://dx.doi.org/10.1186/1756-0500-4-253 |
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author | Morgan, Angharad R Han, Dug Yeo Thompson, John MD Mitchell, Edwin A Ferguson, Lynnette R |
author_facet | Morgan, Angharad R Han, Dug Yeo Thompson, John MD Mitchell, Edwin A Ferguson, Lynnette R |
author_sort | Morgan, Angharad R |
collection | PubMed |
description | BACKGROUND: Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of childhood obesity in a New Zealand population. FINDINGS: 546 samples from the Auckland Birthweight Collaborative (ABC) study were genotyped for the three MMP-2 promoter SNPs -1306 C/T (rs243865), -1575G/A (rs243866) and -790 T/G (rs243864) using the Sequenom genotyping platform. The results demonstrated that an MMP-2 promoter haplotype is associated with PBF in New Zealand 7 year old children. CONCLUSION: We have previously determined that environmental factors are associated with differences in PBF in this study group, and now we have demonstrated a possible genetic contribution. |
format | Online Article Text |
id | pubmed-3154167 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-31541672011-08-11 Analysis of MMP2 promoter polymorphisms in childhood obesity Morgan, Angharad R Han, Dug Yeo Thompson, John MD Mitchell, Edwin A Ferguson, Lynnette R BMC Res Notes Short Report BACKGROUND: Several lines of evidence suggest a possible functional role of Matrix metalloproteinase -2 (MMP-2) in obesity. The aim of this study was to evaluate the role of MMP-2 promoter polymorphisms in percentage body fat (PBF) as a measure of childhood obesity in a New Zealand population. FINDINGS: 546 samples from the Auckland Birthweight Collaborative (ABC) study were genotyped for the three MMP-2 promoter SNPs -1306 C/T (rs243865), -1575G/A (rs243866) and -790 T/G (rs243864) using the Sequenom genotyping platform. The results demonstrated that an MMP-2 promoter haplotype is associated with PBF in New Zealand 7 year old children. CONCLUSION: We have previously determined that environmental factors are associated with differences in PBF in this study group, and now we have demonstrated a possible genetic contribution. BioMed Central 2011-07-21 /pmc/articles/PMC3154167/ /pubmed/21777433 http://dx.doi.org/10.1186/1756-0500-4-253 Text en Copyright ©2011 Morgan et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Report Morgan, Angharad R Han, Dug Yeo Thompson, John MD Mitchell, Edwin A Ferguson, Lynnette R Analysis of MMP2 promoter polymorphisms in childhood obesity |
title | Analysis of MMP2 promoter polymorphisms in childhood obesity |
title_full | Analysis of MMP2 promoter polymorphisms in childhood obesity |
title_fullStr | Analysis of MMP2 promoter polymorphisms in childhood obesity |
title_full_unstemmed | Analysis of MMP2 promoter polymorphisms in childhood obesity |
title_short | Analysis of MMP2 promoter polymorphisms in childhood obesity |
title_sort | analysis of mmp2 promoter polymorphisms in childhood obesity |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154167/ https://www.ncbi.nlm.nih.gov/pubmed/21777433 http://dx.doi.org/10.1186/1756-0500-4-253 |
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