The Effect of the Potential PhoQ Histidine Kinase Inhibitors on Shigella flexneri Virulence

PhoQ/PhoP is an important two-component system that regulates Shigella virulence. We explored whether the PhoQ/PhoP system is a promising target for new antibiotics against S. flexneri infection. By using a high-throughput screen and enzymatic activity coupled assay, four compounds were found as pot...

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Detalles Bibliográficos
Autores principales: Cai, Xia, Zhang, Jian, Chen, Mingliang, Wu, Yang, Wang, Xueqing, Chen, Jiayu, Zhang, Junqin, Shen, Xu, Qu, Di, Jiang, Hualiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154276/
https://www.ncbi.nlm.nih.gov/pubmed/21853073
http://dx.doi.org/10.1371/journal.pone.0023100

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