ADP-Ribosylation Factor 6 Mediates E-Cadherin Recovery by Chemical Chaperones

E-cadherin plays a powerful tumor suppressor role. Germline E-cadherin mutations justify 30% of Hereditary Diffuse Gastric Cancer (HDGC) and missense mutations are found in 30% of these families. We found possible to restore in vitro mutant E-cadherin associated to HDGC syndrome by using Chemical Ch...

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Detalles Bibliográficos
Autores principales: Figueiredo, Joana, Simões-Correia, Joana, Söderberg, Ola, Suriano, Gianpaolo, Seruca, Raquel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154279/
https://www.ncbi.nlm.nih.gov/pubmed/21853084
http://dx.doi.org/10.1371/journal.pone.0023188

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