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Clinicopathologic Study on Combined Hepatocellular Carcinoma and Cholangiocarcinoma: with Emphasis on the Intermediate Cell Morphology

Combined hepatocellular carcinoma and cholangiocarcinoma (combined HCC-CC) is a rare subtype of primary liver cancer. We investigated the histopathologic features of transitional or intermediate areas in 21 combined HCC-CCs and immunophenotypes using different hepatic progenitor cell markers (CK7, C...

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Autores principales: Park, Ho Sung, Bae, Jun Sang, Jang, Kyu Yun, Lee, Ju Hyung, Yu, Hee Chul, Jung, Ji Hyeon, Cho, Baik Hwan, Chung, Myoung Ja, Moon, Woo Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154337/
https://www.ncbi.nlm.nih.gov/pubmed/21860552
http://dx.doi.org/10.3346/jkms.2011.26.8.1023
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author Park, Ho Sung
Bae, Jun Sang
Jang, Kyu Yun
Lee, Ju Hyung
Yu, Hee Chul
Jung, Ji Hyeon
Cho, Baik Hwan
Chung, Myoung Ja
Moon, Woo Sung
author_facet Park, Ho Sung
Bae, Jun Sang
Jang, Kyu Yun
Lee, Ju Hyung
Yu, Hee Chul
Jung, Ji Hyeon
Cho, Baik Hwan
Chung, Myoung Ja
Moon, Woo Sung
author_sort Park, Ho Sung
collection PubMed
description Combined hepatocellular carcinoma and cholangiocarcinoma (combined HCC-CC) is a rare subtype of primary liver cancer. We investigated the histopathologic features of transitional or intermediate areas in 21 combined HCC-CCs and immunophenotypes using different hepatic progenitor cell markers (CK7, CK19, c-kit, NCAM, and EpCAM). Major histologic findings of transitional or intermediate areas of 21 combined HCC-CCs included strands/trabeculae of small, uniform, oval-shaped cells with scant cytoplasm and hyperchromatic nuclei embedded within an abundant stroma, small cells with an antler-like anastomosing pattern, and solid nests of intermediate hepatocyte-like cells surrounded by small cells in periphery, in order of frequency. The intermediate area of one tumor was composed predominantly of spindle cells arranged in short fascicles. Immunophenotype of tumor cells with intermediate morphology suggested a progenitor cell origin for this tumor. Clinical findings of combined HCC-CC showed a closer resemblance with those of HCC than those of CC. In univariate analysis, tumor size, TNM stage, and serum alpha-fetoprotein levels showed a significant association with poor patient survival. Serum alpha-fetoprotein level was an independent prognostic indicator in multivariate analysis. In conclusion, an awareness of the clinicopathologic features, specifically the various morphologic features of intermediate areas in this tumor, is essential for prevention of potential misdiagnosis as another tumor.
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spelling pubmed-31543372011-08-22 Clinicopathologic Study on Combined Hepatocellular Carcinoma and Cholangiocarcinoma: with Emphasis on the Intermediate Cell Morphology Park, Ho Sung Bae, Jun Sang Jang, Kyu Yun Lee, Ju Hyung Yu, Hee Chul Jung, Ji Hyeon Cho, Baik Hwan Chung, Myoung Ja Moon, Woo Sung J Korean Med Sci Original Article Combined hepatocellular carcinoma and cholangiocarcinoma (combined HCC-CC) is a rare subtype of primary liver cancer. We investigated the histopathologic features of transitional or intermediate areas in 21 combined HCC-CCs and immunophenotypes using different hepatic progenitor cell markers (CK7, CK19, c-kit, NCAM, and EpCAM). Major histologic findings of transitional or intermediate areas of 21 combined HCC-CCs included strands/trabeculae of small, uniform, oval-shaped cells with scant cytoplasm and hyperchromatic nuclei embedded within an abundant stroma, small cells with an antler-like anastomosing pattern, and solid nests of intermediate hepatocyte-like cells surrounded by small cells in periphery, in order of frequency. The intermediate area of one tumor was composed predominantly of spindle cells arranged in short fascicles. Immunophenotype of tumor cells with intermediate morphology suggested a progenitor cell origin for this tumor. Clinical findings of combined HCC-CC showed a closer resemblance with those of HCC than those of CC. In univariate analysis, tumor size, TNM stage, and serum alpha-fetoprotein levels showed a significant association with poor patient survival. Serum alpha-fetoprotein level was an independent prognostic indicator in multivariate analysis. In conclusion, an awareness of the clinicopathologic features, specifically the various morphologic features of intermediate areas in this tumor, is essential for prevention of potential misdiagnosis as another tumor. The Korean Academy of Medical Sciences 2011-08 2011-07-27 /pmc/articles/PMC3154337/ /pubmed/21860552 http://dx.doi.org/10.3346/jkms.2011.26.8.1023 Text en © 2011 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Park, Ho Sung
Bae, Jun Sang
Jang, Kyu Yun
Lee, Ju Hyung
Yu, Hee Chul
Jung, Ji Hyeon
Cho, Baik Hwan
Chung, Myoung Ja
Moon, Woo Sung
Clinicopathologic Study on Combined Hepatocellular Carcinoma and Cholangiocarcinoma: with Emphasis on the Intermediate Cell Morphology
title Clinicopathologic Study on Combined Hepatocellular Carcinoma and Cholangiocarcinoma: with Emphasis on the Intermediate Cell Morphology
title_full Clinicopathologic Study on Combined Hepatocellular Carcinoma and Cholangiocarcinoma: with Emphasis on the Intermediate Cell Morphology
title_fullStr Clinicopathologic Study on Combined Hepatocellular Carcinoma and Cholangiocarcinoma: with Emphasis on the Intermediate Cell Morphology
title_full_unstemmed Clinicopathologic Study on Combined Hepatocellular Carcinoma and Cholangiocarcinoma: with Emphasis on the Intermediate Cell Morphology
title_short Clinicopathologic Study on Combined Hepatocellular Carcinoma and Cholangiocarcinoma: with Emphasis on the Intermediate Cell Morphology
title_sort clinicopathologic study on combined hepatocellular carcinoma and cholangiocarcinoma: with emphasis on the intermediate cell morphology
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154337/
https://www.ncbi.nlm.nih.gov/pubmed/21860552
http://dx.doi.org/10.3346/jkms.2011.26.8.1023
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