Cargando…

hSulf-1 Gene Exhibits Anticancer Efficacy through Negatively Regulating VEGFR-2 Signaling in Human Cancers

BACKGROUND: Human sulfatase 1 (hSulf-1) is a heparin-degrading endosulfatase that desulfates cell surface heparan sulfate proteoglycans (HSPGs) in extracellular matrix and negatively modulates heparin-binding growth factor and cytokine signaling in cell proliferation. But hSulf-1 function is more co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ji, Weidan, Yang, Jiahe, Wang, Duanming, Cao, Lu, Tan, Weifeng, Qian, Haihua, Sun, Bin, Qian, Qijun, Yin, Zhengfeng, Wu, Mengchao, Su, Changqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154391/ https://www.ncbi.nlm.nih.gov/pubmed/21853101 http://dx.doi.org/10.1371/journal.pone.0023274

Ejemplares similares

Sulfatase 1 (hSulf-1) reverses basic fibroblast growth factor-stimulated signaling and inhibits growth of hepatocellular carcinoma in animal model
por: Xu, Gaoya, et al.
Publicado: (2014)

hSulf-1 inhibits cell proliferation and migration and promotes apoptosis by suppressing stat3 signaling in hepatocellular carcinoma
por: LIU, LING, et al.
Publicado: (2014)

EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression
por: Lin, Zong-Shin, et al.
Publicado: (2023)

Mass spectrometry analysis of the human endosulfatase Hsulf-2
por: Seffouh, Ilham, et al.
Publicado: (2019)

Desulfation of Heparan Sulfate by Sulf1 and Sulf2 Is Required for Corticospinal Tract Formation
por: Okada, Takuya, et al.
Publicado: (2017)

Context Dependent Sulf1/Sulf2 Functional Divergence in Endothelial Cell Activity
por: Justo, Tiago, et al.
Publicado: (2022)

HSulf-1 and palbociclib exert synergistic antitumor effects on RB-positive triple-negative breast cancer
por: Chen, Fengxia, et al.
Publicado: (2020)

Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage
por: Otsuki, Shuhei, et al.
Publicado: (2008)

Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer
por: Roy, Debarshi, et al.
Publicado: (2014)

Secreted Sulfatases Sulf1 and Sulf2 Have Overlapping yet Essential Roles in Mouse Neonatal Survival
por: Holst, Charles R., et al.
Publicado: (2007)

OCT4 Positively Regulates Survivin Expression to Promote Cancer Cell Proliferation and Leads to Poor Prognosis in Esophageal Squamous Cell Carcinoma
por: Li, Chunguang, et al.
Publicado: (2012)

Erratum to: Loss of HSulf-1 promotes altered lipid metabolism in ovarian cancer
por: Roy, Debarshi, et al.
Publicado: (2014)

Differential involvement of the extracellular 6-O-endosulfatases Sulf1 and Sulf2 in brain development and neuronal and behavioural plasticity
por: Kalus, Ina, et al.
Publicado: (2009)

OCT4 increases BIRC5 and CCND1 expression and promotes cancer progression in hepatocellular carcinoma
por: Cao, Lu, et al.
Publicado: (2013)

HS and Inflammation: A Potential Playground for the Sulfs?
por: El Masri, Rana, et al.
Publicado: (2020)

Extracellular Heparan 6-O-Endosulfatases SULF1 and SULF2 in Head and Neck Squamous Cell Carcinoma and Other Malignancies
por: Yang, Yang, et al.
Publicado: (2022)

Glycomics Analysis of Mammalian Heparan Sulfates Modified by the Human Extracellular Sulfatase HSulf2
por: Staples, Gregory O., et al.
Publicado: (2011)

Loss of HSulf-1: The Missing Link between Autophagy and Lipid Droplets in Ovarian Cancer
por: Roy, Debarshi, et al.
Publicado: (2017)

Abnormal Pyramidal Decussation and Bilateral Projection of the Corticospinal Tract Axons in Mice Lacking the Heparan Sulfate Endosulfatases, Sulf1 and Sulf2
por: Aizawa, Satoshi, et al.
Publicado: (2020)

SULFs in human neoplasia: implication as progression and prognosis factors
por: Bret, Caroline, et al.
Publicado: (2011)

Enhanced levels of Hsulf-1 interfere with heparin-binding growth factor signaling in pancreatic cancer
por: Li, Junsheng, et al.
Publicado: (2005)

HSulf-1 deficiency dictates a metabolic reprograming of glycolysis and TCA cycle in ovarian cancer
por: Mondal, Susmita, et al.
Publicado: (2015)

SulfAtlas, the sulfatase database: state of the art and new developments
por: Stam, Mark, et al.
Publicado: (2022)

The prognostic value and immunological role of SULF2 in adrenocortical carcinoma
por: Yan, Jiusong, et al.
Publicado: (2023)

Novel Substituted Thiophenes and Sulf-Polyacetylene Ester from Echinops ritro L.
por: Li, Liang-Bo, et al.
Publicado: (2019)

Sulf1 and Sulf2 Differentially Modulate Heparan Sulfate Proteoglycan Sulfation during Postnatal Cerebellum Development: Evidence for Neuroprotective and Neurite Outgrowth Promoting Functions
por: Kalus, Ina, et al.
Publicado: (2015)

Research Progress of Small Molecule VEGFR/c-Met Inhibitors as Anticancer Agents (2016–Present)
por: Zhang, Qian, et al.
Publicado: (2020)

HSULF-1 inhibits ERK and AKT signaling and decreases cell viability in vitro in human lung epithelial cells
por: Zhang, Huiying, et al.
Publicado: (2012)

Use of MicroRNA Let-7 to Control the Replication Specificity of Oncolytic Adenovirus in Hepatocellular Carcinoma Cells
por: Jin, Huajun, et al.
Publicado: (2011)

Intratumoral Hepatic Stellate Cells as a Poor Prognostic Marker and a New Treatment Target for Hepatocellular Carcinoma
por: Sun, Bin, et al.
Publicado: (2013)

Post-Synthetic Regulation of HS Structure: The Yin and Yang of the Sulfs in Cancer
por: Vivès, Romain R., et al.
Publicado: (2014)

Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines
por: Cao, Lu, et al.
Publicado: (2011)

Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis
por: Lemjabbar-Alaoui, Hassan, et al.
Publicado: (2009)

SULF2 Expression Is a Potential Diagnostic and Prognostic Marker in Lung Cancer
por: Lui, Natalie S., et al.
Publicado: (2016)

SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells
por: Vicente, Carolina M, et al.
Publicado: (2015)

Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish
por: Schenk, Heiko, et al.
Publicado: (2019)

Vitamin D Enhances Anticancer Properties of Cediranib, a VEGFR Inhibitor, by Modulation of VEGFR2 Expression in Melanoma Cells
por: Piotrowska, Anna, et al.
Publicado: (2021)

Transcriptional factor OCT4 promotes esophageal cancer metastasis by inducing epithelial-mesenchymal transition through VEGF-C/VEGFR-3 signaling pathway
por: Li, Chunguang, et al.
Publicado: (2017)

SULF2 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells through the ERK/AKT signaling pathway
por: Jiang, Tao, et al.
Publicado: (2020)

Albendazole repurposing on VEGFR-2 for possible anticancer application: In-silico analysis
por: Gaikwad, Nikita Maruti, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_j8et2kcqj0ki4is54qljlsabve