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hSulf-1 Gene Exhibits Anticancer Efficacy through Negatively Regulating VEGFR-2 Signaling in Human Cancers

BACKGROUND: Human sulfatase 1 (hSulf-1) is a heparin-degrading endosulfatase that desulfates cell surface heparan sulfate proteoglycans (HSPGs) in extracellular matrix and negatively modulates heparin-binding growth factor and cytokine signaling in cell proliferation. But hSulf-1 function is more co...

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Detalles Bibliográficos
Autores principales:	Ji, Weidan, Yang, Jiahe, Wang, Duanming, Cao, Lu, Tan, Weifeng, Qian, Haihua, Sun, Bin, Qian, Qijun, Yin, Zhengfeng, Wu, Mengchao, Su, Changqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154391/ https://www.ncbi.nlm.nih.gov/pubmed/21853101 http://dx.doi.org/10.1371/journal.pone.0023274

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