Flanking Bases Influence the Nature of DNA Distortion by Platinum 1,2-Intrastrand (GG) Cross-Links

The differences in efficacy and molecular mechanisms of platinum anti-cancer drugs cisplatin (CP) and oxaliplatin (OX) are thought to be partially due to the differences in the DNA conformations of the CP and OX adducts that form on adjacent guanines on DNA, which in turn influence the binding of da...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhattacharyya, Debadeep, Ramachandran, Srinivas, Sharma, Shantanu, Pathmasiri, Wimal, King, Candice L., Baskerville-Abraham, Irene, Boysen, Gunnar, Swenberg, James A., Campbell, Sharon L., Dokholyan, Nikolay V., Chaney, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154474/
https://www.ncbi.nlm.nih.gov/pubmed/21853154
http://dx.doi.org/10.1371/journal.pone.0023582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154474/
https://www.ncbi.nlm.nih.gov/pubmed/21853154
http://dx.doi.org/10.1371/journal.pone.0023582

Ejemplares similares