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An Integrated Drosophila Model System Reveals Unique Properties for F14512, a Novel Polyamine-Containing Anticancer Drug That Targets Topoisomerase II

F14512 is a novel anti-tumor molecule based on an epipodophyllotoxin core coupled to a cancer-cell vectoring spermine moiety. This polyamine linkage is assumed to ensure the preferential uptake of F14512 by cancer cells, strong interaction with DNA and potent inhibition of topoisomerase II (Topo II)...

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Detalles Bibliográficos
Autores principales:	Chelouah, Sonia, Monod-Wissler, Caroline, Bailly, Christian, Barret, Jean-Marc, Guilbaud, Nicolas, Vispé, Stéphane, Käs, Emmanuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154508/ https://www.ncbi.nlm.nih.gov/pubmed/21853156 http://dx.doi.org/10.1371/journal.pone.0023597

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