Octa-Arginine Mediated Delivery of Wild-Type Lnk Protein Inhibits TPO-Induced M-MOK Megakaryoblastic Leukemic Cell Growth by Promoting Apoptosis

BACKGROUND: Lnk plays a non-redundant role by negatively regulating cytokine signaling of TPO, SCF or EPO. Retroviral expression of Lnk has been shown to suppress hematopoietic leukemic cell proliferation indicating its therapeutic value in cancer therapy. However, retroviral gene delivery carries r...

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Detalles Bibliográficos
Autores principales: Looi, Chung Yeng, Imanishi, Miki, Takaki, Satoshi, Sato, Miki, Chiba, Natsuko, Sasahara, Yoji, Futaki, Shiroh, Tsuchiya, Shigeru, Kumaki, Satoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154509/
https://www.ncbi.nlm.nih.gov/pubmed/21853157
http://dx.doi.org/10.1371/journal.pone.0023640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154509/
https://www.ncbi.nlm.nih.gov/pubmed/21853157
http://dx.doi.org/10.1371/journal.pone.0023640

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