PU.1 and Haematopoietic Cell Fate: Dosage Matters

The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will disc...

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Detalles Bibliográficos
Autores principales: Mak, Ka Sin, Funnell, Alister P. W., Pearson, Richard C. M., Crossley, Merlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2011
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154517/
https://www.ncbi.nlm.nih.gov/pubmed/21845190
http://dx.doi.org/10.1155/2011/808524
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author Mak, Ka Sin
Funnell, Alister P. W.
Pearson, Richard C. M.
Crossley, Merlin
author_facet Mak, Ka Sin
Funnell, Alister P. W.
Pearson, Richard C. M.
Crossley, Merlin
author_sort Mak, Ka Sin
collection PubMed
description The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will discuss how a range of experiments in cell lines and mutant and transgenic mouse models have enhanced our knowledge of the mechanisms by which PU.1 drives lineage-specific differentiation during haematopoiesis.
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spelling pubmed-31545172011-08-15 PU.1 and Haematopoietic Cell Fate: Dosage Matters Mak, Ka Sin Funnell, Alister P. W. Pearson, Richard C. M. Crossley, Merlin Int J Cell Biol Review Article The ETS family transcription factor PU.1 is a key regulator of haematopoietic differentiation. Its expression is dynamically controlled throughout haematopoiesis in order to direct appropriate lineage specification. Elucidating the biological role of PU.1 has proved challenging. This paper will discuss how a range of experiments in cell lines and mutant and transgenic mouse models have enhanced our knowledge of the mechanisms by which PU.1 drives lineage-specific differentiation during haematopoiesis. Hindawi Publishing Corporation 2011 2011-08-10 /pmc/articles/PMC3154517/ /pubmed/21845190 http://dx.doi.org/10.1155/2011/808524 Text en Copyright © 2011 Ka Sin Mak et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Mak, Ka Sin
Funnell, Alister P. W.
Pearson, Richard C. M.
Crossley, Merlin
PU.1 and Haematopoietic Cell Fate: Dosage Matters
title PU.1 and Haematopoietic Cell Fate: Dosage Matters
title_full PU.1 and Haematopoietic Cell Fate: Dosage Matters
title_fullStr PU.1 and Haematopoietic Cell Fate: Dosage Matters
title_full_unstemmed PU.1 and Haematopoietic Cell Fate: Dosage Matters
title_short PU.1 and Haematopoietic Cell Fate: Dosage Matters
title_sort pu.1 and haematopoietic cell fate: dosage matters
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154517/
https://www.ncbi.nlm.nih.gov/pubmed/21845190
http://dx.doi.org/10.1155/2011/808524
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AT crossleymerlin pu1andhaematopoieticcellfatedosagematters

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