Cargando…
The Cytokine Network of Acute HIV Infection: A Promising Target for Vaccines and Therapy to Reduce Viral Set-Point?
Cytokines play a central role in the pathogenesis of many diseases, including HIV infection. However, the role of the cytokine network in early HIV infection is only now starting to be elucidated. A number of studies conducted in recent years have indicated that cytokines of the acute/early stages o...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154847/ https://www.ncbi.nlm.nih.gov/pubmed/21852945 http://dx.doi.org/10.1371/journal.ppat.1002055 |
_version_ | 1782210039185932288 |
---|---|
author | Katsikis, Peter D. Mueller, Yvonne M. Villinger, François |
author_facet | Katsikis, Peter D. Mueller, Yvonne M. Villinger, François |
author_sort | Katsikis, Peter D. |
collection | PubMed |
description | Cytokines play a central role in the pathogenesis of many diseases, including HIV infection. However, the role of the cytokine network in early HIV infection is only now starting to be elucidated. A number of studies conducted in recent years have indicated that cytokines of the acute/early stages of HIV and SIV infection can impact viral set-point months later, and this is of critical importance since viral set-point during chronic HIV infection affects virus transmission and disease progression. This raises the question whether modulating the cytokine environment during acute/early HIV infection can be a target for novel approaches to develop a vaccine and therapeutics. In this review we focus on the kinetics and function of cytokines during acute HIV and SIV infection and how these may impact viral set-point. We also discuss unresolved questions that are essential for our understanding of the role of acute infection cytokines in HIV infection and that, if answered, may suggest novel therapeutic and vaccine strategies to control the worldwide HIV pandemic. |
format | Online Article Text |
id | pubmed-3154847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31548472011-08-18 The Cytokine Network of Acute HIV Infection: A Promising Target for Vaccines and Therapy to Reduce Viral Set-Point? Katsikis, Peter D. Mueller, Yvonne M. Villinger, François PLoS Pathog Review Cytokines play a central role in the pathogenesis of many diseases, including HIV infection. However, the role of the cytokine network in early HIV infection is only now starting to be elucidated. A number of studies conducted in recent years have indicated that cytokines of the acute/early stages of HIV and SIV infection can impact viral set-point months later, and this is of critical importance since viral set-point during chronic HIV infection affects virus transmission and disease progression. This raises the question whether modulating the cytokine environment during acute/early HIV infection can be a target for novel approaches to develop a vaccine and therapeutics. In this review we focus on the kinetics and function of cytokines during acute HIV and SIV infection and how these may impact viral set-point. We also discuss unresolved questions that are essential for our understanding of the role of acute infection cytokines in HIV infection and that, if answered, may suggest novel therapeutic and vaccine strategies to control the worldwide HIV pandemic. Public Library of Science 2011-08-11 /pmc/articles/PMC3154847/ /pubmed/21852945 http://dx.doi.org/10.1371/journal.ppat.1002055 Text en Katsikis et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Review Katsikis, Peter D. Mueller, Yvonne M. Villinger, François The Cytokine Network of Acute HIV Infection: A Promising Target for Vaccines and Therapy to Reduce Viral Set-Point? |
title | The Cytokine Network of Acute HIV Infection: A Promising Target for Vaccines and Therapy to Reduce Viral Set-Point? |
title_full | The Cytokine Network of Acute HIV Infection: A Promising Target for Vaccines and Therapy to Reduce Viral Set-Point? |
title_fullStr | The Cytokine Network of Acute HIV Infection: A Promising Target for Vaccines and Therapy to Reduce Viral Set-Point? |
title_full_unstemmed | The Cytokine Network of Acute HIV Infection: A Promising Target for Vaccines and Therapy to Reduce Viral Set-Point? |
title_short | The Cytokine Network of Acute HIV Infection: A Promising Target for Vaccines and Therapy to Reduce Viral Set-Point? |
title_sort | cytokine network of acute hiv infection: a promising target for vaccines and therapy to reduce viral set-point? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154847/ https://www.ncbi.nlm.nih.gov/pubmed/21852945 http://dx.doi.org/10.1371/journal.ppat.1002055 |
work_keys_str_mv | AT katsikispeterd thecytokinenetworkofacutehivinfectionapromisingtargetforvaccinesandtherapytoreduceviralsetpoint AT muelleryvonnem thecytokinenetworkofacutehivinfectionapromisingtargetforvaccinesandtherapytoreduceviralsetpoint AT villingerfrancois thecytokinenetworkofacutehivinfectionapromisingtargetforvaccinesandtherapytoreduceviralsetpoint AT katsikispeterd cytokinenetworkofacutehivinfectionapromisingtargetforvaccinesandtherapytoreduceviralsetpoint AT muelleryvonnem cytokinenetworkofacutehivinfectionapromisingtargetforvaccinesandtherapytoreduceviralsetpoint AT villingerfrancois cytokinenetworkofacutehivinfectionapromisingtargetforvaccinesandtherapytoreduceviralsetpoint |