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The landscape of recombination in African Americans
Recombination, together with mutation, is the ultimate source of genetic variation in populations. We leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing-over at each position in the genome, based on abou...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154982/ https://www.ncbi.nlm.nih.gov/pubmed/21775986 http://dx.doi.org/10.1038/nature10336 |
| _version_ | 1782210065515675648 |
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| author | Hinch, Anjali G. Tandon, Arti Patterson, Nick Song, Yunli Rohland, Nadin Palmer, Cameron D. Chen, Gary K. Wang, Kai Buxbaum, Sarah G. Akylbekova, Meggie Aldrich, Melinda C. Ambrosone, Christine B. Amos, Christopher Bandera, Elisa V. Berndt, Sonja I. Bernstein, Leslie Blot, William J. Bock, Cathryn H. Boerwinkle, Eric Cai, Qiuyin Caporaso, Neil Casey, Graham Cupples, L. Adrienne Deming, Sandra L. Diver, W. Ryan Divers, Jasmin Fornage, Myriam Gillanders, Elizabeth M. Glessner, Joseph Harris, Curtis C. Hu, Jennifer J. Ingles, Sue A. Isaacs, Williams John, Esther M. Kao, W. H. Linda Keating, Brendan Kittles, Rick A. Kolonel, Laurence N. Larkin, Emma Le Marchand, Loic McNeill, Lorna H. Millikan, Robert C. Murphy, Adam Musani, Solomon Neslund-Dudas, Christine Nyante, Sarah Papanicolaou, George J. Press, Michael F. Psaty, Bruce M. Reiner, Alex P. Rich, Stephen S. Rodriguez-Gil, Jorge L. Rotter, Jerome I. Rybicki, Benjamin A. Schwartz, Ann G. Signorello, Lisa B. Spitz, Margaret Strom, Sara S. Thun, Michael J. Tucker, Margaret A. Wang, Zhaoming Wiencke, John K. Witte, John S. Wrensch, Margaret Wu, Xifeng Yamamura, Yuko Zanetti, Krista A. Zheng, Wei Ziegler, Regina G. Zhu, Xiaofeng Redline, Susan Hirschhorn, Joel N. Henderson, Brian E. Taylor, Herman A. Price, Alkes L. Hakonarson, Hakon Chanock, Stephen J. Haiman, Christopher A. Wilson, James G. Reich, David Myers, Simon R. |
| author_facet | Hinch, Anjali G. Tandon, Arti Patterson, Nick Song, Yunli Rohland, Nadin Palmer, Cameron D. Chen, Gary K. Wang, Kai Buxbaum, Sarah G. Akylbekova, Meggie Aldrich, Melinda C. Ambrosone, Christine B. Amos, Christopher Bandera, Elisa V. Berndt, Sonja I. Bernstein, Leslie Blot, William J. Bock, Cathryn H. Boerwinkle, Eric Cai, Qiuyin Caporaso, Neil Casey, Graham Cupples, L. Adrienne Deming, Sandra L. Diver, W. Ryan Divers, Jasmin Fornage, Myriam Gillanders, Elizabeth M. Glessner, Joseph Harris, Curtis C. Hu, Jennifer J. Ingles, Sue A. Isaacs, Williams John, Esther M. Kao, W. H. Linda Keating, Brendan Kittles, Rick A. Kolonel, Laurence N. Larkin, Emma Le Marchand, Loic McNeill, Lorna H. Millikan, Robert C. Murphy, Adam Musani, Solomon Neslund-Dudas, Christine Nyante, Sarah Papanicolaou, George J. Press, Michael F. Psaty, Bruce M. Reiner, Alex P. Rich, Stephen S. Rodriguez-Gil, Jorge L. Rotter, Jerome I. Rybicki, Benjamin A. Schwartz, Ann G. Signorello, Lisa B. Spitz, Margaret Strom, Sara S. Thun, Michael J. Tucker, Margaret A. Wang, Zhaoming Wiencke, John K. Witte, John S. Wrensch, Margaret Wu, Xifeng Yamamura, Yuko Zanetti, Krista A. Zheng, Wei Ziegler, Regina G. Zhu, Xiaofeng Redline, Susan Hirschhorn, Joel N. Henderson, Brian E. Taylor, Herman A. Price, Alkes L. Hakonarson, Hakon Chanock, Stephen J. Haiman, Christopher A. Wilson, James G. Reich, David Myers, Simon R. |
| author_sort | Hinch, Anjali G. |
| collection | PubMed |
| description | Recombination, together with mutation, is the ultimate source of genetic variation in populations. We leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing-over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9 (P<10(−245)). We identify a 17 base pair DNA sequence motif that is enriched in these hotspots, and is an excellent match to the predicted binding target of African-enriched alleles of PRDM9. |
| format | Online Article Text |
| id | pubmed-3154982 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-31549822012-02-11 The landscape of recombination in African Americans Hinch, Anjali G. Tandon, Arti Patterson, Nick Song, Yunli Rohland, Nadin Palmer, Cameron D. Chen, Gary K. Wang, Kai Buxbaum, Sarah G. Akylbekova, Meggie Aldrich, Melinda C. Ambrosone, Christine B. Amos, Christopher Bandera, Elisa V. Berndt, Sonja I. Bernstein, Leslie Blot, William J. Bock, Cathryn H. Boerwinkle, Eric Cai, Qiuyin Caporaso, Neil Casey, Graham Cupples, L. Adrienne Deming, Sandra L. Diver, W. Ryan Divers, Jasmin Fornage, Myriam Gillanders, Elizabeth M. Glessner, Joseph Harris, Curtis C. Hu, Jennifer J. Ingles, Sue A. Isaacs, Williams John, Esther M. Kao, W. H. Linda Keating, Brendan Kittles, Rick A. Kolonel, Laurence N. Larkin, Emma Le Marchand, Loic McNeill, Lorna H. Millikan, Robert C. Murphy, Adam Musani, Solomon Neslund-Dudas, Christine Nyante, Sarah Papanicolaou, George J. Press, Michael F. Psaty, Bruce M. Reiner, Alex P. Rich, Stephen S. Rodriguez-Gil, Jorge L. Rotter, Jerome I. Rybicki, Benjamin A. Schwartz, Ann G. Signorello, Lisa B. Spitz, Margaret Strom, Sara S. Thun, Michael J. Tucker, Margaret A. Wang, Zhaoming Wiencke, John K. Witte, John S. Wrensch, Margaret Wu, Xifeng Yamamura, Yuko Zanetti, Krista A. Zheng, Wei Ziegler, Regina G. Zhu, Xiaofeng Redline, Susan Hirschhorn, Joel N. Henderson, Brian E. Taylor, Herman A. Price, Alkes L. Hakonarson, Hakon Chanock, Stephen J. Haiman, Christopher A. Wilson, James G. Reich, David Myers, Simon R. Nature Article Recombination, together with mutation, is the ultimate source of genetic variation in populations. We leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing-over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9 (P<10(−245)). We identify a 17 base pair DNA sequence motif that is enriched in these hotspots, and is an excellent match to the predicted binding target of African-enriched alleles of PRDM9. 2011-07-20 /pmc/articles/PMC3154982/ /pubmed/21775986 http://dx.doi.org/10.1038/nature10336 Text en Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Hinch, Anjali G. Tandon, Arti Patterson, Nick Song, Yunli Rohland, Nadin Palmer, Cameron D. Chen, Gary K. Wang, Kai Buxbaum, Sarah G. Akylbekova, Meggie Aldrich, Melinda C. Ambrosone, Christine B. Amos, Christopher Bandera, Elisa V. Berndt, Sonja I. Bernstein, Leslie Blot, William J. Bock, Cathryn H. Boerwinkle, Eric Cai, Qiuyin Caporaso, Neil Casey, Graham Cupples, L. Adrienne Deming, Sandra L. Diver, W. Ryan Divers, Jasmin Fornage, Myriam Gillanders, Elizabeth M. Glessner, Joseph Harris, Curtis C. Hu, Jennifer J. Ingles, Sue A. Isaacs, Williams John, Esther M. Kao, W. H. Linda Keating, Brendan Kittles, Rick A. Kolonel, Laurence N. Larkin, Emma Le Marchand, Loic McNeill, Lorna H. Millikan, Robert C. Murphy, Adam Musani, Solomon Neslund-Dudas, Christine Nyante, Sarah Papanicolaou, George J. Press, Michael F. Psaty, Bruce M. Reiner, Alex P. Rich, Stephen S. Rodriguez-Gil, Jorge L. Rotter, Jerome I. Rybicki, Benjamin A. Schwartz, Ann G. Signorello, Lisa B. Spitz, Margaret Strom, Sara S. Thun, Michael J. Tucker, Margaret A. Wang, Zhaoming Wiencke, John K. Witte, John S. Wrensch, Margaret Wu, Xifeng Yamamura, Yuko Zanetti, Krista A. Zheng, Wei Ziegler, Regina G. Zhu, Xiaofeng Redline, Susan Hirschhorn, Joel N. Henderson, Brian E. Taylor, Herman A. Price, Alkes L. Hakonarson, Hakon Chanock, Stephen J. Haiman, Christopher A. Wilson, James G. Reich, David Myers, Simon R. The landscape of recombination in African Americans |
| title | The landscape of recombination in African Americans |
| title_full | The landscape of recombination in African Americans |
| title_fullStr | The landscape of recombination in African Americans |
| title_full_unstemmed | The landscape of recombination in African Americans |
| title_short | The landscape of recombination in African Americans |
| title_sort | landscape of recombination in african americans |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3154982/ https://www.ncbi.nlm.nih.gov/pubmed/21775986 http://dx.doi.org/10.1038/nature10336 |
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