Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome

Systemic juvenile idiopathic arthritis (sJIA) is a systemic inflammatory disease characterized by arthritis, spiking fever and a skin rash that is frequently complicated by macrophage activation syndrome (MAS), a life-threatening disorder. We report a 22-month-old girl with sJIA who developed severe...

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Autores principales: Shigemura, Tomonari, Yamazaki, Takashi, Hara, Yosuke, Ou, Jing-Ni, Stevens, Anne M, Ochs, Hans D, Koike, Kenichi, Agematsu, Kazunaga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155148/
https://www.ncbi.nlm.nih.gov/pubmed/21749729
http://dx.doi.org/10.1186/1546-0096-9-15
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author Shigemura, Tomonari
Yamazaki, Takashi
Hara, Yosuke
Ou, Jing-Ni
Stevens, Anne M
Ochs, Hans D
Koike, Kenichi
Agematsu, Kazunaga
author_facet Shigemura, Tomonari
Yamazaki, Takashi
Hara, Yosuke
Ou, Jing-Ni
Stevens, Anne M
Ochs, Hans D
Koike, Kenichi
Agematsu, Kazunaga
author_sort Shigemura, Tomonari
collection PubMed
description Systemic juvenile idiopathic arthritis (sJIA) is a systemic inflammatory disease characterized by arthritis, spiking fever and a skin rash that is frequently complicated by macrophage activation syndrome (MAS), a life-threatening disorder. We report a 22-month-old girl with sJIA who developed severe MAS but was successfully treated with corticosteroids, cyclosporin A, and non-steroidal anti-inflammatory drugs by monitoring serum IL-18 levels. IL-18 is an extremely useful cytokine for monitoring the activity of sJIA and MAS, and serum IL-18 can be used as an indicator for the effectiveness of treatment and the decision to discontinue therapy.
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spelling pubmed-31551482011-08-13 Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome Shigemura, Tomonari Yamazaki, Takashi Hara, Yosuke Ou, Jing-Ni Stevens, Anne M Ochs, Hans D Koike, Kenichi Agematsu, Kazunaga Pediatr Rheumatol Online J Case Report Systemic juvenile idiopathic arthritis (sJIA) is a systemic inflammatory disease characterized by arthritis, spiking fever and a skin rash that is frequently complicated by macrophage activation syndrome (MAS), a life-threatening disorder. We report a 22-month-old girl with sJIA who developed severe MAS but was successfully treated with corticosteroids, cyclosporin A, and non-steroidal anti-inflammatory drugs by monitoring serum IL-18 levels. IL-18 is an extremely useful cytokine for monitoring the activity of sJIA and MAS, and serum IL-18 can be used as an indicator for the effectiveness of treatment and the decision to discontinue therapy. BioMed Central 2011-07-13 /pmc/articles/PMC3155148/ /pubmed/21749729 http://dx.doi.org/10.1186/1546-0096-9-15 Text en Copyright ©2011 Shigemura et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shigemura, Tomonari
Yamazaki, Takashi
Hara, Yosuke
Ou, Jing-Ni
Stevens, Anne M
Ochs, Hans D
Koike, Kenichi
Agematsu, Kazunaga
Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome
title Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome
title_full Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome
title_fullStr Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome
title_full_unstemmed Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome
title_short Monitoring serum IL-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome
title_sort monitoring serum il-18 levels is useful for treatment of a patient with systemic juvenile idiopathic arthritis complicated by macrophage activation syndrome
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155148/
https://www.ncbi.nlm.nih.gov/pubmed/21749729
http://dx.doi.org/10.1186/1546-0096-9-15
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