Biocatalytic Organic Synthesis of Optically Pure (S)-Scoulerine and Berbine and Benzylisoquinoline Alkaloids

[Image: see text] A chemoenzymatic approach for the asymmetric total synthesis of the title compounds is described that employs an enantioselective oxidative C–C bond formation catalyzed by berberine bridge enzyme (BBE) in the asymmetric key step. This unique reaction yielded enantiomerically pure (...

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Detalles Bibliográficos
Autores principales: Schrittwieser, Joerg H., Resch, Verena, Wallner, Silvia, Lienhart, Wolf-Dieter, Sattler, Johann H., Resch, Jasmin, Macheroux, Peter, Kroutil, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2011
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155283/
https://www.ncbi.nlm.nih.gov/pubmed/21739961
http://dx.doi.org/10.1021/jo201056f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155283/
https://www.ncbi.nlm.nih.gov/pubmed/21739961
http://dx.doi.org/10.1021/jo201056f

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