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Subunit Interface Residues F129 and H294 of Human RAD51 Are Essential for Recombinase Function
RAD51 mediated homologous recombinational repair (HRR) of DNA double-strand breaks (DSBs) is essential to maintain genomic integrity. RAD51 forms a nucleoprotein filament (NPF) that catalyzes the fundamental homologous pairing and strand exchange reaction (recombinase) required for HRR. Based on str...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155514/ https://www.ncbi.nlm.nih.gov/pubmed/21857994 http://dx.doi.org/10.1371/journal.pone.0023071 |