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Effectiveness of Non-Adjuvanted Pandemic Influenza A Vaccines for Preventing Pandemic Influenza Acute Respiratory Illness Visits in 4 U.S. Communities
We estimated the effectiveness of four monovalent pandemic influenza A (H1N1) vaccines (three unadjuvanted inactivated, one live attenuated) available in the U.S. during the pandemic. Patients with acute respiratory illness presenting to inpatient and outpatient facilities affiliated with four colla...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155536/ https://www.ncbi.nlm.nih.gov/pubmed/21857999 http://dx.doi.org/10.1371/journal.pone.0023085 |
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author | Griffin, Marie R. Monto, Arnold S. Belongia, Edward A. Treanor, John J. Chen, Qingxia Chen, Jufu Talbot, H. Keipp Ohmit, Suzanne E. Coleman, Laura A. Lofthus, Gerry Petrie, Joshua G. Meece, Jennifer K. Hall, Caroline Breese Williams, John V. Gargiullo, Paul Berman, LaShondra Shay, David K. |
author_facet | Griffin, Marie R. Monto, Arnold S. Belongia, Edward A. Treanor, John J. Chen, Qingxia Chen, Jufu Talbot, H. Keipp Ohmit, Suzanne E. Coleman, Laura A. Lofthus, Gerry Petrie, Joshua G. Meece, Jennifer K. Hall, Caroline Breese Williams, John V. Gargiullo, Paul Berman, LaShondra Shay, David K. |
author_sort | Griffin, Marie R. |
collection | PubMed |
description | We estimated the effectiveness of four monovalent pandemic influenza A (H1N1) vaccines (three unadjuvanted inactivated, one live attenuated) available in the U.S. during the pandemic. Patients with acute respiratory illness presenting to inpatient and outpatient facilities affiliated with four collaborating institutions were prospectively recruited, consented, and tested for influenza. Analyses were restricted to October 2009 through April 2010, when pandemic vaccine was available. Patients testing positive for pandemic influenza by real-time RT-PCR were cases; those testing negative were controls. Vaccine effectiveness was estimated in logistic regression models adjusted for study community, patient age, timing of illness, insurance status, enrollment site, and presence of high-risk medical conditions. Pandemic virus was detected in 1,011 (15%) of 6,757 enrolled patients. Fifteen (1%) of 1,011 influenza positive cases and 1,042 (18%) of 5,746 test-negative controls had record-verified pandemic vaccination >14 days prior to illness onset. Adjusted effectiveness (95% confidence interval) for pandemic vaccines combined was 56% (23%, 75%). Adjusted effectiveness for inactivated vaccines alone (79% of total) was 62% (25%, 81%) overall and 32% (−92%, 76%), 89% (15%, 99%), and −6% (−231%, 66%) in those aged 0.5 to 9, 10 to 49, and 50+ years, respectively. Effectiveness for the live attenuated vaccine in those aged 2 to 49 years was only demonstrated if vaccination >7 rather than >14 days prior to illness onset was considered (61%∶ 12%, 82%). Inactivated non-adjuvanted pandemic vaccines offered significant protection against confirmed pandemic influenza-associated medical care visits in young adults. |
format | Online Article Text |
id | pubmed-3155536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-31555362011-08-19 Effectiveness of Non-Adjuvanted Pandemic Influenza A Vaccines for Preventing Pandemic Influenza Acute Respiratory Illness Visits in 4 U.S. Communities Griffin, Marie R. Monto, Arnold S. Belongia, Edward A. Treanor, John J. Chen, Qingxia Chen, Jufu Talbot, H. Keipp Ohmit, Suzanne E. Coleman, Laura A. Lofthus, Gerry Petrie, Joshua G. Meece, Jennifer K. Hall, Caroline Breese Williams, John V. Gargiullo, Paul Berman, LaShondra Shay, David K. PLoS One Research Article We estimated the effectiveness of four monovalent pandemic influenza A (H1N1) vaccines (three unadjuvanted inactivated, one live attenuated) available in the U.S. during the pandemic. Patients with acute respiratory illness presenting to inpatient and outpatient facilities affiliated with four collaborating institutions were prospectively recruited, consented, and tested for influenza. Analyses were restricted to October 2009 through April 2010, when pandemic vaccine was available. Patients testing positive for pandemic influenza by real-time RT-PCR were cases; those testing negative were controls. Vaccine effectiveness was estimated in logistic regression models adjusted for study community, patient age, timing of illness, insurance status, enrollment site, and presence of high-risk medical conditions. Pandemic virus was detected in 1,011 (15%) of 6,757 enrolled patients. Fifteen (1%) of 1,011 influenza positive cases and 1,042 (18%) of 5,746 test-negative controls had record-verified pandemic vaccination >14 days prior to illness onset. Adjusted effectiveness (95% confidence interval) for pandemic vaccines combined was 56% (23%, 75%). Adjusted effectiveness for inactivated vaccines alone (79% of total) was 62% (25%, 81%) overall and 32% (−92%, 76%), 89% (15%, 99%), and −6% (−231%, 66%) in those aged 0.5 to 9, 10 to 49, and 50+ years, respectively. Effectiveness for the live attenuated vaccine in those aged 2 to 49 years was only demonstrated if vaccination >7 rather than >14 days prior to illness onset was considered (61%∶ 12%, 82%). Inactivated non-adjuvanted pandemic vaccines offered significant protection against confirmed pandemic influenza-associated medical care visits in young adults. Public Library of Science 2011-08-12 /pmc/articles/PMC3155536/ /pubmed/21857999 http://dx.doi.org/10.1371/journal.pone.0023085 Text en Griffin et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Griffin, Marie R. Monto, Arnold S. Belongia, Edward A. Treanor, John J. Chen, Qingxia Chen, Jufu Talbot, H. Keipp Ohmit, Suzanne E. Coleman, Laura A. Lofthus, Gerry Petrie, Joshua G. Meece, Jennifer K. Hall, Caroline Breese Williams, John V. Gargiullo, Paul Berman, LaShondra Shay, David K. Effectiveness of Non-Adjuvanted Pandemic Influenza A Vaccines for Preventing Pandemic Influenza Acute Respiratory Illness Visits in 4 U.S. Communities |
title | Effectiveness of Non-Adjuvanted Pandemic Influenza A Vaccines for Preventing Pandemic Influenza Acute Respiratory Illness Visits in 4 U.S. Communities |
title_full | Effectiveness of Non-Adjuvanted Pandemic Influenza A Vaccines for Preventing Pandemic Influenza Acute Respiratory Illness Visits in 4 U.S. Communities |
title_fullStr | Effectiveness of Non-Adjuvanted Pandemic Influenza A Vaccines for Preventing Pandemic Influenza Acute Respiratory Illness Visits in 4 U.S. Communities |
title_full_unstemmed | Effectiveness of Non-Adjuvanted Pandemic Influenza A Vaccines for Preventing Pandemic Influenza Acute Respiratory Illness Visits in 4 U.S. Communities |
title_short | Effectiveness of Non-Adjuvanted Pandemic Influenza A Vaccines for Preventing Pandemic Influenza Acute Respiratory Illness Visits in 4 U.S. Communities |
title_sort | effectiveness of non-adjuvanted pandemic influenza a vaccines for preventing pandemic influenza acute respiratory illness visits in 4 u.s. communities |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155536/ https://www.ncbi.nlm.nih.gov/pubmed/21857999 http://dx.doi.org/10.1371/journal.pone.0023085 |
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