Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1

Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair. However, whether condensin I physically associates with DNA damage sites and how...

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Detalles Bibliográficos
Autores principales: Kong, Xiangduo, Stephens, Jared, Ball, Alexander R., Heale, Jason T., Newkirk, Daniel A., Berns, Michael W., Yokomori, Kyoko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155556/
https://www.ncbi.nlm.nih.gov/pubmed/21858164
http://dx.doi.org/10.1371/journal.pone.0023548
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author Kong, Xiangduo
Stephens, Jared
Ball, Alexander R.
Heale, Jason T.
Newkirk, Daniel A.
Berns, Michael W.
Yokomori, Kyoko
author_facet Kong, Xiangduo
Stephens, Jared
Ball, Alexander R.
Heale, Jason T.
Newkirk, Daniel A.
Berns, Michael W.
Yokomori, Kyoko
author_sort Kong, Xiangduo
collection PubMed
description Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair. However, whether condensin I physically associates with DNA damage sites and how PARP1 may contribute to this process were unclear. We found that condensin I is preferentially recruited to DNA damage sites enriched for base damage. This process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I.
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spelling pubmed-31555562011-08-19 Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1 Kong, Xiangduo Stephens, Jared Ball, Alexander R. Heale, Jason T. Newkirk, Daniel A. Berns, Michael W. Yokomori, Kyoko PLoS One Research Article Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with PARP1 in response to DNA damage and plays a role in single-strand break repair. However, whether condensin I physically associates with DNA damage sites and how PARP1 may contribute to this process were unclear. We found that condensin I is preferentially recruited to DNA damage sites enriched for base damage. This process is dictated by PARP1 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I. Public Library of Science 2011-08-12 /pmc/articles/PMC3155556/ /pubmed/21858164 http://dx.doi.org/10.1371/journal.pone.0023548 Text en Kong et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Kong, Xiangduo
Stephens, Jared
Ball, Alexander R.
Heale, Jason T.
Newkirk, Daniel A.
Berns, Michael W.
Yokomori, Kyoko
Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1
title Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1
title_full Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1
title_fullStr Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1
title_full_unstemmed Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1
title_short Condensin I Recruitment to Base Damage-Enriched DNA Lesions Is Modulated by PARP1
title_sort condensin i recruitment to base damage-enriched dna lesions is modulated by parp1
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155556/
https://www.ncbi.nlm.nih.gov/pubmed/21858164
http://dx.doi.org/10.1371/journal.pone.0023548
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