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Nitric Oxide Signaling Modulates Synaptic Transmission during Early Postnatal Development

Early γ-aminobutyric acid mediated (GABAergic) synaptic transmission and correlated neuronal activity are fundamental to network formation; however, their regulation during early postnatal development is poorly understood. Nitric oxide (NO) is an important retrograde messenger at glutamatergic synap...

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Autores principales: Cserép, Csaba, Szőnyi, András, Veres, Judit M., Németh, Beáta, Szabadits, Eszter, de Vente, Jan, Hájos, Norbert, Freund, Tamás F., Nyiri, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155603/
https://www.ncbi.nlm.nih.gov/pubmed/21282319
http://dx.doi.org/10.1093/cercor/bhq281
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author Cserép, Csaba
Szőnyi, András
Veres, Judit M.
Németh, Beáta
Szabadits, Eszter
de Vente, Jan
Hájos, Norbert
Freund, Tamás F.
Nyiri, Gábor
author_facet Cserép, Csaba
Szőnyi, András
Veres, Judit M.
Németh, Beáta
Szabadits, Eszter
de Vente, Jan
Hájos, Norbert
Freund, Tamás F.
Nyiri, Gábor
author_sort Cserép, Csaba
collection PubMed
description Early γ-aminobutyric acid mediated (GABAergic) synaptic transmission and correlated neuronal activity are fundamental to network formation; however, their regulation during early postnatal development is poorly understood. Nitric oxide (NO) is an important retrograde messenger at glutamatergic synapses, and it was recently shown to play an important role also at GABAergic synapses in the adult brain. The subcellular localization and network effect of this signaling pathway during early development are so far unexplored, but its disruption at this early age is known to lead to profound morphological and functional alterations. Here, we provide functional evidence—using whole-cell recording—that NO signaling modulates not only glutamatergic but also GABAergic synaptic transmission in the mouse hippocampus during the early postnatal period. We identified the precise subcellular localization of key elements of the underlying molecular cascade using immunohistochemistry at the light—and electron microscopic levels. As predicted by these morpho-functional data, multineuron calcium imaging in acute slices revealed that this NO-signaling machinery is involved also in the control of synchronous network activity patterns. We suggest that the retrograde NO-signaling system is ideally suited to fulfill a general presynaptic regulatory role and may effectively fine-tune network activity during early postnatal development, while GABAergic transmission is still depolarizing.
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spelling pubmed-31556032011-08-15 Nitric Oxide Signaling Modulates Synaptic Transmission during Early Postnatal Development Cserép, Csaba Szőnyi, András Veres, Judit M. Németh, Beáta Szabadits, Eszter de Vente, Jan Hájos, Norbert Freund, Tamás F. Nyiri, Gábor Cereb Cortex Articles Early γ-aminobutyric acid mediated (GABAergic) synaptic transmission and correlated neuronal activity are fundamental to network formation; however, their regulation during early postnatal development is poorly understood. Nitric oxide (NO) is an important retrograde messenger at glutamatergic synapses, and it was recently shown to play an important role also at GABAergic synapses in the adult brain. The subcellular localization and network effect of this signaling pathway during early development are so far unexplored, but its disruption at this early age is known to lead to profound morphological and functional alterations. Here, we provide functional evidence—using whole-cell recording—that NO signaling modulates not only glutamatergic but also GABAergic synaptic transmission in the mouse hippocampus during the early postnatal period. We identified the precise subcellular localization of key elements of the underlying molecular cascade using immunohistochemistry at the light—and electron microscopic levels. As predicted by these morpho-functional data, multineuron calcium imaging in acute slices revealed that this NO-signaling machinery is involved also in the control of synchronous network activity patterns. We suggest that the retrograde NO-signaling system is ideally suited to fulfill a general presynaptic regulatory role and may effectively fine-tune network activity during early postnatal development, while GABAergic transmission is still depolarizing. Oxford University Press 2011-09 2011-01-31 /pmc/articles/PMC3155603/ /pubmed/21282319 http://dx.doi.org/10.1093/cercor/bhq281 Text en © The Authors 2011. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.5), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Cserép, Csaba
Szőnyi, András
Veres, Judit M.
Németh, Beáta
Szabadits, Eszter
de Vente, Jan
Hájos, Norbert
Freund, Tamás F.
Nyiri, Gábor
Nitric Oxide Signaling Modulates Synaptic Transmission during Early Postnatal Development
title Nitric Oxide Signaling Modulates Synaptic Transmission during Early Postnatal Development
title_full Nitric Oxide Signaling Modulates Synaptic Transmission during Early Postnatal Development
title_fullStr Nitric Oxide Signaling Modulates Synaptic Transmission during Early Postnatal Development
title_full_unstemmed Nitric Oxide Signaling Modulates Synaptic Transmission during Early Postnatal Development
title_short Nitric Oxide Signaling Modulates Synaptic Transmission during Early Postnatal Development
title_sort nitric oxide signaling modulates synaptic transmission during early postnatal development
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155603/
https://www.ncbi.nlm.nih.gov/pubmed/21282319
http://dx.doi.org/10.1093/cercor/bhq281
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