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Engineering and optimization of the mir-106b-cluster for ectopic expression of multiplexed anti-HIV RNAs

Many microRNAs (miRNAs) are encoded within the introns of RNA Pol II transcripts, often as polycistronic precursors. Here we demonstrate the optimization of an intron encoding three endogenous miRNAs for the ectopic expression of heterologous anti-HIV-1 siRNAs processed from a single RNA polymerase...

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Detalles Bibliográficos
Autores principales:	Aagaard, Lars, Zhang, Jane, von Eije, Karin J., Li, Haitang, Sœtrom, Pål, Amarzguioui, Mohammed, Rossi, John J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2008
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155610/ https://www.ncbi.nlm.nih.gov/pubmed/18800151 http://dx.doi.org/10.1038/gt.2008.147

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