Non-Bisphosphonate Inhibitors of Isoprenoid Biosynthesis Identified via Computer-Aided Drug Design

The relaxed complex scheme, a virtual-screening methodology that accounts for protein receptor flexibility, was used to identify a low-micromolar, non-bisphosphonate inhibitor of farnesyl diphosphate synthase. Serendipitously, we also found that several predicted farnesyl diphosphate synthase inhibi...

Descripción completa

Detalles Bibliográficos
Autores principales: Durrant, Jacob D, Cao, Rong, Gorfe, Alemayehu A, Zhu, Wei, Li, Jikun, Sankovsky, Anna, Oldfield, Eric, McCammon, J Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2011
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155669/
https://www.ncbi.nlm.nih.gov/pubmed/21696546
http://dx.doi.org/10.1111/j.1747-0285.2011.01164.x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155669/
https://www.ncbi.nlm.nih.gov/pubmed/21696546
http://dx.doi.org/10.1111/j.1747-0285.2011.01164.x

Ejemplares similares