A comparative study of fragment screening methods on the p38α kinase: new methods, new insights

The stress-activated kinase p38α was used to evaluate a fragment-based drug discovery approach using the BioFocus fragment library. Compounds were screened by surface plasmon resonance (SPR) on a Biacore(™) T100 against p38α and two selectivity targets. A sub-set of our library was the focus of deta...

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Detalles Bibliográficos
Autores principales: Pollack, Scott J., Beyer, Kim S., Lock, Christopher, Müller, Ilka, Sheppard, David, Lipkin, Mike, Hardick, David, Blurton, Peter, Leonard, Philip M., Hubbard, Paul A., Todd, Daniel, Richardson, Christine M., Ahrens, Thomas, Baader, Manuel, Hafenbradl, Doris O., Hilyard, Kate, Bürli, Roland W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155752/
https://www.ncbi.nlm.nih.gov/pubmed/21732248
http://dx.doi.org/10.1007/s10822-011-9454-9

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