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Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients

Aims. Patients with diabetic nephropathy are reported to have a high prevalence of left ventricular structural and functional abnormalities. This study was designed to assess the determinants of left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) in diabetic patients at...

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Autores principales: Chen, Szu-Chia, Chang, Jer-Ming, Liu, Wan-Chun, Tsai, Yi-Chun, Tsai, Jer-Chia, Su, Ho-Ming, Hwang, Shang-Jyh, Chen, Hung-Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155789/
https://www.ncbi.nlm.nih.gov/pubmed/21860616
http://dx.doi.org/10.1155/2012/789325
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author Chen, Szu-Chia
Chang, Jer-Ming
Liu, Wan-Chun
Tsai, Yi-Chun
Tsai, Jer-Chia
Su, Ho-Ming
Hwang, Shang-Jyh
Chen, Hung-Chun
author_facet Chen, Szu-Chia
Chang, Jer-Ming
Liu, Wan-Chun
Tsai, Yi-Chun
Tsai, Jer-Chia
Su, Ho-Ming
Hwang, Shang-Jyh
Chen, Hung-Chun
author_sort Chen, Szu-Chia
collection PubMed
description Aims. Patients with diabetic nephropathy are reported to have a high prevalence of left ventricular structural and functional abnormalities. This study was designed to assess the determinants of left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) in diabetic patients at various stages of chronic kidney disease (CKD). Methods. This cross-sectional study enrolled 285 diabetic patients with CKD stages 3 to 5 from our outpatient department of internal medicine. Clinical and echocardiographic parameters were compared and analyzed. Results. We found a significant stepwise increase in LVMI (P < 0.001), LVH (P < 0.001), and LVEF <55% (P = 0.013) and a stepwise decrease in LVEF (P = 0.038) corresponding to advance in CKD stages. Conclusions. Our findings suggest that increases in LVMI and decreases in LVEF coincide with advances in CKD stages in patients with diabetes.
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spelling pubmed-31557892011-08-22 Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients Chen, Szu-Chia Chang, Jer-Ming Liu, Wan-Chun Tsai, Yi-Chun Tsai, Jer-Chia Su, Ho-Ming Hwang, Shang-Jyh Chen, Hung-Chun Exp Diabetes Res Clinical Study Aims. Patients with diabetic nephropathy are reported to have a high prevalence of left ventricular structural and functional abnormalities. This study was designed to assess the determinants of left ventricular mass index (LVMI) and left ventricular ejection fraction (LVEF) in diabetic patients at various stages of chronic kidney disease (CKD). Methods. This cross-sectional study enrolled 285 diabetic patients with CKD stages 3 to 5 from our outpatient department of internal medicine. Clinical and echocardiographic parameters were compared and analyzed. Results. We found a significant stepwise increase in LVMI (P < 0.001), LVH (P < 0.001), and LVEF <55% (P = 0.013) and a stepwise decrease in LVEF (P = 0.038) corresponding to advance in CKD stages. Conclusions. Our findings suggest that increases in LVMI and decreases in LVEF coincide with advances in CKD stages in patients with diabetes. Hindawi Publishing Corporation 2012 2011-08-11 /pmc/articles/PMC3155789/ /pubmed/21860616 http://dx.doi.org/10.1155/2012/789325 Text en Copyright © 2012 Szu-Chia Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Chen, Szu-Chia
Chang, Jer-Ming
Liu, Wan-Chun
Tsai, Yi-Chun
Tsai, Jer-Chia
Su, Ho-Ming
Hwang, Shang-Jyh
Chen, Hung-Chun
Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients
title Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients
title_full Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients
title_fullStr Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients
title_full_unstemmed Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients
title_short Stepwise Increases in Left Ventricular Mass Index and Decreases in Left Ventricular Ejection Fraction Correspond with the Stages of Chronic Kidney Disease in Diabetes Patients
title_sort stepwise increases in left ventricular mass index and decreases in left ventricular ejection fraction correspond with the stages of chronic kidney disease in diabetes patients
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155789/
https://www.ncbi.nlm.nih.gov/pubmed/21860616
http://dx.doi.org/10.1155/2012/789325
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