GEP100-Arf6-AMAP1-Cortactin Pathway Frequently Used in Cancer Invasion Is Activated by VEGFR2 to Promote Angiogenesis

Angiogenesis and cancer invasiveness greatly contribute to cancer malignancy. Arf6 and its effector, AMAP1, are frequently overexpressed in breast cancer, and constitute a central pathway to induce the invasion and metastasis. In this pathway, Arf6 is activated by EGFR via GEP100. Arf6 is highly exp...

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Detalles Bibliográficos
Autores principales: Hashimoto, Ari, Hashimoto, Shigeru, Ando, Ryo, Noda, Kosuke, Ogawa, Eiji, Kotani, Hirokazu, Hirose, Mayumi, Menju, Toshi, Morishige, Masaki, Manabe, Toshiaki, Toda, Yoshinobu, Ishida, Susumu, Sabe, Hisataka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156124/
https://www.ncbi.nlm.nih.gov/pubmed/21858086
http://dx.doi.org/10.1371/journal.pone.0023359

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