Comparison of the Safety and Pharmacokinetics of ST-246® after IV Infusion or Oral Administration in Mice, Rabbits and Monkeys

BACKGROUND: ST-246® is an antiviral, orally bioavailable small molecule in clinical development for treatment of orthopoxvirus infections. An intravenous (IV) formulation may be required for some hospitalized patients who are unable to take oral medication. An IV formulation has been evaluated in th...

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Detalles Bibliográficos
Autores principales: Chen, Yali, Amantana, Adams, Tyavanagimatt, Shanthakumar R., Zima, Daniela, Yan, X. Steven, Kasi, Gopi, Weeks, Morgan, Stone, Melialani A., Weimers, William C., Samuel, Peter, Tan, Ying, Jones, Kevin F., Lee, Daniel R., Kickner, Shirley S., Saville, Bradley M., Lauzon, Martin, McIntyre, Alan, Honeychurch, Kady M., Jordan, Robert, Hruby, Dennis E., Leeds, Janet M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156126/
https://www.ncbi.nlm.nih.gov/pubmed/21858040
http://dx.doi.org/10.1371/journal.pone.0023237

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