Transcriptomic Analysis Brings New Insight into the Biological Role of the Prion Protein during Mouse Embryogenesis

The biological function of the Prion protein remains largely unknown but recent data revealed its implication in early zebrafish and mammalian embryogenesis. To gain further insight into its biological function, comparative transcriptomic analysis between FVB/N and FVB/N Prnp knockout mice was perfo...

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Autores principales: Khalifé, Manal, Young, Rachel, Passet, Bruno, Halliez, Sophie, Vilotte, Marthe, Jaffrezic, Florence, Marthey, Sylvain, Béringue, Vincent, Vaiman, Daniel, Le Provost, Fabienne, Laude, Hubert, Vilotte, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156130/
https://www.ncbi.nlm.nih.gov/pubmed/21858045
http://dx.doi.org/10.1371/journal.pone.0023253
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author Khalifé, Manal
Young, Rachel
Passet, Bruno
Halliez, Sophie
Vilotte, Marthe
Jaffrezic, Florence
Marthey, Sylvain
Béringue, Vincent
Vaiman, Daniel
Le Provost, Fabienne
Laude, Hubert
Vilotte, Jean-Luc
author_facet Khalifé, Manal
Young, Rachel
Passet, Bruno
Halliez, Sophie
Vilotte, Marthe
Jaffrezic, Florence
Marthey, Sylvain
Béringue, Vincent
Vaiman, Daniel
Le Provost, Fabienne
Laude, Hubert
Vilotte, Jean-Luc
author_sort Khalifé, Manal
collection PubMed
description The biological function of the Prion protein remains largely unknown but recent data revealed its implication in early zebrafish and mammalian embryogenesis. To gain further insight into its biological function, comparative transcriptomic analysis between FVB/N and FVB/N Prnp knockout mice was performed at early embryonic stages. RNAseq analysis revealed the differential expression of 73 and 263 genes at E6.5 and E7.5, respectively. The related metabolic pathways identified in this analysis partially overlap with those described in PrP1 and PrP2 knockdown zebrafish embryos and prion-infected mammalian brains and emphasize a potentially important role for the PrP family genes in early developmental processes.
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spelling pubmed-31561302011-08-19 Transcriptomic Analysis Brings New Insight into the Biological Role of the Prion Protein during Mouse Embryogenesis Khalifé, Manal Young, Rachel Passet, Bruno Halliez, Sophie Vilotte, Marthe Jaffrezic, Florence Marthey, Sylvain Béringue, Vincent Vaiman, Daniel Le Provost, Fabienne Laude, Hubert Vilotte, Jean-Luc PLoS One Research Article The biological function of the Prion protein remains largely unknown but recent data revealed its implication in early zebrafish and mammalian embryogenesis. To gain further insight into its biological function, comparative transcriptomic analysis between FVB/N and FVB/N Prnp knockout mice was performed at early embryonic stages. RNAseq analysis revealed the differential expression of 73 and 263 genes at E6.5 and E7.5, respectively. The related metabolic pathways identified in this analysis partially overlap with those described in PrP1 and PrP2 knockdown zebrafish embryos and prion-infected mammalian brains and emphasize a potentially important role for the PrP family genes in early developmental processes. Public Library of Science 2011-08-15 /pmc/articles/PMC3156130/ /pubmed/21858045 http://dx.doi.org/10.1371/journal.pone.0023253 Text en Khalifé et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Khalifé, Manal
Young, Rachel
Passet, Bruno
Halliez, Sophie
Vilotte, Marthe
Jaffrezic, Florence
Marthey, Sylvain
Béringue, Vincent
Vaiman, Daniel
Le Provost, Fabienne
Laude, Hubert
Vilotte, Jean-Luc
Transcriptomic Analysis Brings New Insight into the Biological Role of the Prion Protein during Mouse Embryogenesis
title Transcriptomic Analysis Brings New Insight into the Biological Role of the Prion Protein during Mouse Embryogenesis
title_full Transcriptomic Analysis Brings New Insight into the Biological Role of the Prion Protein during Mouse Embryogenesis
title_fullStr Transcriptomic Analysis Brings New Insight into the Biological Role of the Prion Protein during Mouse Embryogenesis
title_full_unstemmed Transcriptomic Analysis Brings New Insight into the Biological Role of the Prion Protein during Mouse Embryogenesis
title_short Transcriptomic Analysis Brings New Insight into the Biological Role of the Prion Protein during Mouse Embryogenesis
title_sort transcriptomic analysis brings new insight into the biological role of the prion protein during mouse embryogenesis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156130/
https://www.ncbi.nlm.nih.gov/pubmed/21858045
http://dx.doi.org/10.1371/journal.pone.0023253
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