Cargando…

Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials

Critically sized large bone defects commonly result from trauma, radical tumor resections or infections. Currently, massive allografting remain as the clinical standard to treat these critical defects. Unfortunately, allograft healing is limited by the lack of osteogenesis and bio-integration of the...

Descripción completa

Detalles Bibliográficos
Autores principales: Dhillon, Robinder S., Schwarz, Edward M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156480/
https://www.ncbi.nlm.nih.gov/pubmed/21857768
http://dx.doi.org/10.3390/ma4061117
_version_ 1782210194513592320
author Dhillon, Robinder S.
Schwarz, Edward M.
author_facet Dhillon, Robinder S.
Schwarz, Edward M.
author_sort Dhillon, Robinder S.
collection PubMed
description Critically sized large bone defects commonly result from trauma, radical tumor resections or infections. Currently, massive allografting remain as the clinical standard to treat these critical defects. Unfortunately, allograft healing is limited by the lack of osteogenesis and bio-integration of the graft to the host bone. Based on its widely studied anabolic effects on the bone, we have proposed that teriparatide [recombinant parathyroid hormone (PTH(1–34))] could be an effective adjuvant for massive allograft healing. In support of this theory, here we review studies that have demonstrated that intermittent PTH(1–34) treatment enhances and accelerates the skeletal repair process via a number of mechanisms including: effects on mesenchymal stem cells (MSC), angiogenesis, chondrogenesis, bone formation and remodeling. We also review the current literature on the effects of PTH(1–34) therapy on bone healing, and discuss this drug’s long term potential as an adjuvant for endogenous tissue engineering.
format Online
Article
Text
id pubmed-3156480
institution National Center for Biotechnology Information
language English
publishDate 2011
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-31564802012-06-01 Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials Dhillon, Robinder S. Schwarz, Edward M. Materials (Basel) Article Critically sized large bone defects commonly result from trauma, radical tumor resections or infections. Currently, massive allografting remain as the clinical standard to treat these critical defects. Unfortunately, allograft healing is limited by the lack of osteogenesis and bio-integration of the graft to the host bone. Based on its widely studied anabolic effects on the bone, we have proposed that teriparatide [recombinant parathyroid hormone (PTH(1–34))] could be an effective adjuvant for massive allograft healing. In support of this theory, here we review studies that have demonstrated that intermittent PTH(1–34) treatment enhances and accelerates the skeletal repair process via a number of mechanisms including: effects on mesenchymal stem cells (MSC), angiogenesis, chondrogenesis, bone formation and remodeling. We also review the current literature on the effects of PTH(1–34) therapy on bone healing, and discuss this drug’s long term potential as an adjuvant for endogenous tissue engineering. MDPI 2011-06-15 /pmc/articles/PMC3156480/ /pubmed/21857768 http://dx.doi.org/10.3390/ma4061117 Text en © 2011 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Dhillon, Robinder S.
Schwarz, Edward M.
Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials
title Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials
title_full Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials
title_fullStr Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials
title_full_unstemmed Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials
title_short Teriparatide Therapy as an Adjuvant for Tissue Engineering and Integration of Biomaterials
title_sort teriparatide therapy as an adjuvant for tissue engineering and integration of biomaterials
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156480/
https://www.ncbi.nlm.nih.gov/pubmed/21857768
http://dx.doi.org/10.3390/ma4061117
work_keys_str_mv AT dhillonrobinders teriparatidetherapyasanadjuvantfortissueengineeringandintegrationofbiomaterials
AT schwarzedwardm teriparatidetherapyasanadjuvantfortissueengineeringandintegrationofbiomaterials