Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes

The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor su...

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Detalles Bibliográficos
Autores principales: Yu, Elizabeth A., Weaver, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156599/
https://www.ncbi.nlm.nih.gov/pubmed/21566258
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author Yu, Elizabeth A.
Weaver, David R.
author_facet Yu, Elizabeth A.
Weaver, David R.
author_sort Yu, Elizabeth A.
collection PubMed
description The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this Review, we highlight a recent study [Dubrovsky et al., Aging 2: 936-944, 2010] and discuss the much larger field examining the relationship between circadian clock genes, circadian rhythmicity, aging-related phenotypes, and cancer.
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spelling pubmed-31565992011-08-17 Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes Yu, Elizabeth A. Weaver, David R. Aging (Albany NY) Review The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this Review, we highlight a recent study [Dubrovsky et al., Aging 2: 936-944, 2010] and discuss the much larger field examining the relationship between circadian clock genes, circadian rhythmicity, aging-related phenotypes, and cancer. Impact Journals LLC 2011-05-01 /pmc/articles/PMC3156599/ /pubmed/21566258 Text en Copyright: © 2011 Yu and Weaver http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Review
Yu, Elizabeth A.
Weaver, David R.
Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes
title Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes
title_full Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes
title_fullStr Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes
title_full_unstemmed Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes
title_short Disrupting the circadian clock: Gene-specific effects on aging, cancer, and other phenotypes
title_sort disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156599/
https://www.ncbi.nlm.nih.gov/pubmed/21566258
work_keys_str_mv AT yuelizabetha disruptingthecircadianclockgenespecificeffectsonagingcancerandotherphenotypes
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