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Cockayne Syndrome B protein antagonizes OGG1 in modulating CAG repeat length in vivo

OGG1 and MSH2/MSH3 promote CAG repeat expansion at Huntington's disease (HD) locus in vivo during removal of oxidized bases from DNA. CSB, a transcription-coupled repair (TCR) protein, facilitates repair of some of the same oxidative lesions. In vitro, a knock down CSB results in a reduction of...

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Detalles Bibliográficos
Autores principales:	Kovtun, Irina V., Johnson, Kurt O., McMurray, Cynthia T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2011
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156601/ https://www.ncbi.nlm.nih.gov/pubmed/21566259

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