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Mutations in the BRCT binding site of BRCA1 result in hyper-recombination

We introduced a K1702M mutation in the BRCA1 BRCT domain known to prevent the binding of proteins harboring pS-X-X-F motifs such as Abraxas-RAP80, BRIP1, and CtIP. Surprisingly, rather than impairing homologous recombination repair (HRR), expression of K1702M resulted in hyper-recombination coincidi...

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Detalles Bibliográficos
Autores principales:	Dever, Seth M., Golding, Sarah E., Rosenberg, Elizabeth, Adams, Bret R., Idowu, Michael O., Quillin, John M., Valerie, Nicholas, Xu, Bo, Povirk, Lawrence F., Valerie, Kristoffer
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2011
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156602/ https://www.ncbi.nlm.nih.gov/pubmed/21666281

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