Interference between PARPs and SIRT1: a novel approach to healthy ageing?

Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.

Detalles Bibliográficos
Autores principales: CantÓ, Carles, Auwerx, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2011
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156604/
https://www.ncbi.nlm.nih.gov/pubmed/21566260
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author CantÓ, Carles
Auwerx, Johan
author_facet CantÓ, Carles
Auwerx, Johan
author_sort CantÓ, Carles
collection PubMed
description Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.
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spelling pubmed-31566042011-08-17 Interference between PARPs and SIRT1: a novel approach to healthy ageing? CantÓ, Carles Auwerx, Johan Aging (Albany NY) Research Perspective Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators. Impact Journals LLC 2011-05-07 /pmc/articles/PMC3156604/ /pubmed/21566260 Text en Copyright: © 2011 CantÓ and Auwerx http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
spellingShingle Research Perspective
CantÓ, Carles
Auwerx, Johan
Interference between PARPs and SIRT1: a novel approach to healthy ageing?
title Interference between PARPs and SIRT1: a novel approach to healthy ageing?
title_full Interference between PARPs and SIRT1: a novel approach to healthy ageing?
title_fullStr Interference between PARPs and SIRT1: a novel approach to healthy ageing?
title_full_unstemmed Interference between PARPs and SIRT1: a novel approach to healthy ageing?
title_short Interference between PARPs and SIRT1: a novel approach to healthy ageing?
title_sort interference between parps and sirt1: a novel approach to healthy ageing?
topic Research Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156604/
https://www.ncbi.nlm.nih.gov/pubmed/21566260
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AT auwerxjohan interferencebetweenparpsandsirt1anovelapproachtohealthyageing

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