Chagasic Thymic Atrophy Does Not Affect Negative Selection but Results in the Export of Activated CD4(+)CD8(+) T Cells in Severe Forms of Human Disease

Extrathymic CD4(+)CD8(+) double-positive (DP) T cells are increased in some pathophysiological conditions, including infectious diseases. In the murine model of Chagas disease, it has been shown that the protozoan parasite Trypanosoma cruzi is able to target the thymus and induce alterations of the...

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Detalles Bibliográficos
Autores principales: Morrot, Alexandre, Terra-Granado, Eugênia, Pérez, Ana Rosa, Silva-Barbosa, Suse Dayse, Milićević, Novica M., Farias-de-Oliveira, Désio Aurélio, Berbert, Luiz Ricardo, De Meis, Juliana, Takiya, Christina Maeda, Beloscar, Juan, Wang, Xiaoping, Kont, Vivian, Peterson, Pärt, Bottasso, Oscar, Savino, Wilson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156684/
https://www.ncbi.nlm.nih.gov/pubmed/21858238
http://dx.doi.org/10.1371/journal.pntd.0001268

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156684/
https://www.ncbi.nlm.nih.gov/pubmed/21858238
http://dx.doi.org/10.1371/journal.pntd.0001268

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