A cyclopalladated complex interacts with mitochondrial membrane thiol-groups and induces the apoptotic intrinsic pathway in murine and cisplatin-resistant human tumor cells

BACKGROUND: Systemic therapy for cancer metastatic lesions is difficult and generally renders a poor clinical response. Structural analogs of cisplatin, the most widely used synthetic metal complexes, show toxic side-effects and tumor cell resistance. Recently, palladium complexes with increased sta...

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Detalles Bibliográficos
Autores principales: Serrano, Fabiana A, Matsuo, Alisson L, Monteforte, Priscila T, Bechara, Alexandre, Smaili, Soraya S, Santana, Débora P, Rodrigues, Tiago, Pereira, Felipe V, Silva, Luis S, Machado, Joel, Santos, Edson L, Pesquero, João B, Martins, Rafael M, Travassos, Luiz R, Caires, Antonio CF, Rodrigues, Elaine G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156809/
https://www.ncbi.nlm.nih.gov/pubmed/21756336
http://dx.doi.org/10.1186/1471-2407-11-296

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