Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites

A role for PrP in the toxic effect of oligomeric forms of Aβ, implicated in Alzheimer's disease (AD), has been suggested but remains controversial. Here we show that PrP is required for the plasticity-impairing effects of ex vivo material from human AD brain and that standardized Aβ-derived dif...

Descripción completa

Detalles Bibliográficos
Autores principales: Freir, Darragh B., Nicoll, Andrew J., Klyubin, Igor, Panico, Silvia, Mc Donald, Jessica M., Risse, Emmanuel, Asante, Emmanuel A., Farrow, Mark A., Sessions, Richard B., Saibil, Helen R., Clarke, Anthony R., Rowan, Michael J., Walsh, Dominic M., Collinge, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156817/
https://www.ncbi.nlm.nih.gov/pubmed/21654636
http://dx.doi.org/10.1038/ncomms1341

Ejemplares similares

Ejemplares similares