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Glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits
PURPOSE: To evaluate the hypotensive effects of glycyrrhizin (GL) on a rabbit model of ocular hypertension (OH) induced by triamcinolone acetonide (TA). METHODS: Forty New Zealand White Rabbits were divided as follows: control (intravitreal injection of sterile saline solution); GL (intravitreal inj...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Vision
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156820/ https://www.ncbi.nlm.nih.gov/pubmed/21850181 |
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author | Song, Zhengyu Gong, Yuanyuan Liu, Haiyun Ren, Qiushi Sun, Xiaodong |
author_facet | Song, Zhengyu Gong, Yuanyuan Liu, Haiyun Ren, Qiushi Sun, Xiaodong |
author_sort | Song, Zhengyu |
collection | PubMed |
description | PURPOSE: To evaluate the hypotensive effects of glycyrrhizin (GL) on a rabbit model of ocular hypertension (OH) induced by triamcinolone acetonide (TA). METHODS: Forty New Zealand White Rabbits were divided as follows: control (intravitreal injection of sterile saline solution); GL (intravitreal injection of sterile saline solution, then fed with 25mg GL/day); TA (intravitreal TA injection); TA+GL (intravitreal TA injection, then fed with GL) and GL+TA (pre-treated with GL for 3 days, then got TA injection and the following GL treatment). Intraocular pressure (IOP), flash electroretinogram (flash ERG) and flash visual evoked potential (flash VEP) were measured during the follow-up (28 days). The aqueous humor was analyzed, using (1)H-nuclear magnetic resonance spectroscopy and principal components analysis (PCA). RESULTS: IOP elevation was observed in the TA group during the follow-up, compared to the controls (p<0.01). The IOP was decreased in the TA+GL group and the GL+TA group, compared to the TA group (p<0.05). Both in flash ERG and VEP, the amplitudes were decreased, and the implicit time was prolonged in the TA group, compared to the controls (p<0.05); and the parameters were improved after intervention of GL, compared to the TA group (p<0.05). PCA results indicated that TA could affect ocular metabolism (especially the sugar metabolism), and GL could inhibit it. CONCLUSIONS: The administration of GL could suppress OH induced by TA in rabbits, and improve their electrophysiological parameters. Metabolomics is a useful tool in ophthalmology research. Our results indicate that TA-induced ocular metabolism changes could be compensated by GL. |
format | Online Article Text |
id | pubmed-3156820 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Molecular Vision |
record_format | MEDLINE/PubMed |
spelling | pubmed-31568202011-08-17 Glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits Song, Zhengyu Gong, Yuanyuan Liu, Haiyun Ren, Qiushi Sun, Xiaodong Mol Vis Research Article PURPOSE: To evaluate the hypotensive effects of glycyrrhizin (GL) on a rabbit model of ocular hypertension (OH) induced by triamcinolone acetonide (TA). METHODS: Forty New Zealand White Rabbits were divided as follows: control (intravitreal injection of sterile saline solution); GL (intravitreal injection of sterile saline solution, then fed with 25mg GL/day); TA (intravitreal TA injection); TA+GL (intravitreal TA injection, then fed with GL) and GL+TA (pre-treated with GL for 3 days, then got TA injection and the following GL treatment). Intraocular pressure (IOP), flash electroretinogram (flash ERG) and flash visual evoked potential (flash VEP) were measured during the follow-up (28 days). The aqueous humor was analyzed, using (1)H-nuclear magnetic resonance spectroscopy and principal components analysis (PCA). RESULTS: IOP elevation was observed in the TA group during the follow-up, compared to the controls (p<0.01). The IOP was decreased in the TA+GL group and the GL+TA group, compared to the TA group (p<0.05). Both in flash ERG and VEP, the amplitudes were decreased, and the implicit time was prolonged in the TA group, compared to the controls (p<0.05); and the parameters were improved after intervention of GL, compared to the TA group (p<0.05). PCA results indicated that TA could affect ocular metabolism (especially the sugar metabolism), and GL could inhibit it. CONCLUSIONS: The administration of GL could suppress OH induced by TA in rabbits, and improve their electrophysiological parameters. Metabolomics is a useful tool in ophthalmology research. Our results indicate that TA-induced ocular metabolism changes could be compensated by GL. Molecular Vision 2011-08-04 /pmc/articles/PMC3156820/ /pubmed/21850181 Text en Copyright © 2011 Molecular Vision. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Song, Zhengyu Gong, Yuanyuan Liu, Haiyun Ren, Qiushi Sun, Xiaodong Glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits |
title | Glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits |
title_full | Glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits |
title_fullStr | Glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits |
title_full_unstemmed | Glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits |
title_short | Glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits |
title_sort | glycyrrhizin could reduce ocular hypertension induced by triamcinolone acetonide in rabbits |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3156820/ https://www.ncbi.nlm.nih.gov/pubmed/21850181 |
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